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Introducing Human APOE into Aβ Transgenic Mouse Models
Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE(−/−) mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199079/ https://www.ncbi.nlm.nih.gov/pubmed/22028984 http://dx.doi.org/10.4061/2011/810981 |
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author | Tai, Leon M. Youmans, Katherine L. Jungbauer, Lisa Yu, Chunjiang LaDu, Mary Jo |
author_facet | Tai, Leon M. Youmans, Katherine L. Jungbauer, Lisa Yu, Chunjiang LaDu, Mary Jo |
author_sort | Tai, Leon M. |
collection | PubMed |
description | Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE(−/−) mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration. To determine the effects of apoE on Aβ-induced neuropathology, apoE(−/−) mice were crossed with Aβ-Tg mice, resulting in a significant delay in plaque deposition. Surprisingly, crossing human-apoE-Tg mice with apoE(−/−)/Aβ-Tg mice further delayed plaque deposition, which eventually developed in apoE4/Aβ-Tg mice prior to apoE3/Aβ-Tg. One approach to address hAPOE-induced temporal delay in Aβ pathology is an additional insult, like head injury. Another is crossing human-apoE-Tg mice with Aβ-Tg mice that have rapid-onset Aβ pathology. For example, because 5xFAD mice develop plaques by 2 months, the prediction is that human-apoE/5xFAD-Tg mice develop plaques around 6 months and 12 months before other human-apoE/Aβ-Tg mice. Thus, tractable models for human-apoE/Aβ-Tg mice continue to evolve. |
format | Online Article Text |
id | pubmed-3199079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31990792011-10-25 Introducing Human APOE into Aβ Transgenic Mouse Models Tai, Leon M. Youmans, Katherine L. Jungbauer, Lisa Yu, Chunjiang LaDu, Mary Jo Int J Alzheimers Dis Review Article Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE(−/−) mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration. To determine the effects of apoE on Aβ-induced neuropathology, apoE(−/−) mice were crossed with Aβ-Tg mice, resulting in a significant delay in plaque deposition. Surprisingly, crossing human-apoE-Tg mice with apoE(−/−)/Aβ-Tg mice further delayed plaque deposition, which eventually developed in apoE4/Aβ-Tg mice prior to apoE3/Aβ-Tg. One approach to address hAPOE-induced temporal delay in Aβ pathology is an additional insult, like head injury. Another is crossing human-apoE-Tg mice with Aβ-Tg mice that have rapid-onset Aβ pathology. For example, because 5xFAD mice develop plaques by 2 months, the prediction is that human-apoE/5xFAD-Tg mice develop plaques around 6 months and 12 months before other human-apoE/Aβ-Tg mice. Thus, tractable models for human-apoE/Aβ-Tg mice continue to evolve. SAGE-Hindawi Access to Research 2011 2011-10-19 /pmc/articles/PMC3199079/ /pubmed/22028984 http://dx.doi.org/10.4061/2011/810981 Text en Copyright © 2011 Leon M. Tai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tai, Leon M. Youmans, Katherine L. Jungbauer, Lisa Yu, Chunjiang LaDu, Mary Jo Introducing Human APOE into Aβ Transgenic Mouse Models |
title | Introducing Human APOE into Aβ Transgenic Mouse Models |
title_full | Introducing Human APOE into Aβ Transgenic Mouse Models |
title_fullStr | Introducing Human APOE into Aβ Transgenic Mouse Models |
title_full_unstemmed | Introducing Human APOE into Aβ Transgenic Mouse Models |
title_short | Introducing Human APOE into Aβ Transgenic Mouse Models |
title_sort | introducing human apoe into aβ transgenic mouse models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199079/ https://www.ncbi.nlm.nih.gov/pubmed/22028984 http://dx.doi.org/10.4061/2011/810981 |
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