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Introducing Human APOE into Aβ Transgenic Mouse Models

Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE(−/−) mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-i...

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Detalles Bibliográficos
Autores principales:	Tai, Leon M., Youmans, Katherine L., Jungbauer, Lisa, Yu, Chunjiang, LaDu, Mary Jo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE-Hindawi Access to Research 2011
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199079/ https://www.ncbi.nlm.nih.gov/pubmed/22028984 http://dx.doi.org/10.4061/2011/810981

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