Cargando…

The Sarcomeric Z-Disc and Z-Discopathies

The sarcomeric Z-disc defines the lateral borders of the sarcomere and has primarily been seen as a structure important for mechanical stability. This view has changed dramatically within the last one or two decades. A multitude of novel Z-disc proteins and their interacting partners have been ident...

Descripción completa

Detalles Bibliográficos
Autores principales: Knöll, Ralph, Buyandelger, Byambajav, Lab, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199094/
https://www.ncbi.nlm.nih.gov/pubmed/22028589
http://dx.doi.org/10.1155/2011/569628
_version_ 1782214529399128064
author Knöll, Ralph
Buyandelger, Byambajav
Lab, Max
author_facet Knöll, Ralph
Buyandelger, Byambajav
Lab, Max
author_sort Knöll, Ralph
collection PubMed
description The sarcomeric Z-disc defines the lateral borders of the sarcomere and has primarily been seen as a structure important for mechanical stability. This view has changed dramatically within the last one or two decades. A multitude of novel Z-disc proteins and their interacting partners have been identified, which has led to the identification of additional functions and which have now been assigned to this structure. This includes its importance for intracellular signalling, for mechanosensation and mechanotransduction in particular, an emerging importance for protein turnover and autophagy, as well as its molecular links to the t-tubular system and the sarcoplasmic reticulum. Moreover, the discovery of mutations in a wide variety of Z-disc proteins, which lead to perturbations of several of the above-mentioned systems, gives rise to a diverse group of diseases which can be termed Z-discopathies. This paper provides a brief overview of these novel aspects as well as points to future research directions.
format Online
Article
Text
id pubmed-3199094
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-31990942011-10-25 The Sarcomeric Z-Disc and Z-Discopathies Knöll, Ralph Buyandelger, Byambajav Lab, Max J Biomed Biotechnol Review Article The sarcomeric Z-disc defines the lateral borders of the sarcomere and has primarily been seen as a structure important for mechanical stability. This view has changed dramatically within the last one or two decades. A multitude of novel Z-disc proteins and their interacting partners have been identified, which has led to the identification of additional functions and which have now been assigned to this structure. This includes its importance for intracellular signalling, for mechanosensation and mechanotransduction in particular, an emerging importance for protein turnover and autophagy, as well as its molecular links to the t-tubular system and the sarcoplasmic reticulum. Moreover, the discovery of mutations in a wide variety of Z-disc proteins, which lead to perturbations of several of the above-mentioned systems, gives rise to a diverse group of diseases which can be termed Z-discopathies. This paper provides a brief overview of these novel aspects as well as points to future research directions. Hindawi Publishing Corporation 2011 2011-10-18 /pmc/articles/PMC3199094/ /pubmed/22028589 http://dx.doi.org/10.1155/2011/569628 Text en Copyright © 2011 Ralph Knöll et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Knöll, Ralph
Buyandelger, Byambajav
Lab, Max
The Sarcomeric Z-Disc and Z-Discopathies
title The Sarcomeric Z-Disc and Z-Discopathies
title_full The Sarcomeric Z-Disc and Z-Discopathies
title_fullStr The Sarcomeric Z-Disc and Z-Discopathies
title_full_unstemmed The Sarcomeric Z-Disc and Z-Discopathies
title_short The Sarcomeric Z-Disc and Z-Discopathies
title_sort sarcomeric z-disc and z-discopathies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199094/
https://www.ncbi.nlm.nih.gov/pubmed/22028589
http://dx.doi.org/10.1155/2011/569628
work_keys_str_mv AT knollralph thesarcomericzdiscandzdiscopathies
AT buyandelgerbyambajav thesarcomericzdiscandzdiscopathies
AT labmax thesarcomericzdiscandzdiscopathies
AT knollralph sarcomericzdiscandzdiscopathies
AT buyandelgerbyambajav sarcomericzdiscandzdiscopathies
AT labmax sarcomericzdiscandzdiscopathies