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New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis

Diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC) is presently based on mainly clinical symptoms. BPS/IC can be considered as a worst-case scenario of bladder overactivity of unknown origin, including bladder pain. Usually, patients are partially or completely resistant to anticholin...

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Autores principales: Neuhaus, Jochen, Schwalenberg, Thilo, Horn, Lars-Christian, Alexander, Henry, Stolzenburg, Jens-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199109/
https://www.ncbi.nlm.nih.gov/pubmed/22028706
http://dx.doi.org/10.1155/2011/639479
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author Neuhaus, Jochen
Schwalenberg, Thilo
Horn, Lars-Christian
Alexander, Henry
Stolzenburg, Jens-Uwe
author_facet Neuhaus, Jochen
Schwalenberg, Thilo
Horn, Lars-Christian
Alexander, Henry
Stolzenburg, Jens-Uwe
author_sort Neuhaus, Jochen
collection PubMed
description Diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC) is presently based on mainly clinical symptoms. BPS/IC can be considered as a worst-case scenario of bladder overactivity of unknown origin, including bladder pain. Usually, patients are partially or completely resistant to anticholinergic therapy, and therapeutical options are especially restricted in case of BPS/IC. Therefore, early detection of patients prone to develop BPS/IC symptoms is essential for successful therapy. We propose extended diagnostics including molecular markers. Differential diagnosis should be based on three diagnostical “columns”: (i) clinical diagnostics, (ii) histopathology, and (iii) molecular diagnostics. Analysis of molecular alterations of receptor expression in detrusor smooth muscle cells and urothelial integrity is necessary to develop patient-tailored therapeutical concepts. Although more research is needed to elucidate the pathomechanisms involved, extended BPS/IC diagnostics could already be integrated into routine patient care, allowing evidence-based pharmacotherapy of patients with idiopathic bladder overactivity and BPS/IC.
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spelling pubmed-31991092011-10-25 New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis Neuhaus, Jochen Schwalenberg, Thilo Horn, Lars-Christian Alexander, Henry Stolzenburg, Jens-Uwe Adv Urol Research Article Diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC) is presently based on mainly clinical symptoms. BPS/IC can be considered as a worst-case scenario of bladder overactivity of unknown origin, including bladder pain. Usually, patients are partially or completely resistant to anticholinergic therapy, and therapeutical options are especially restricted in case of BPS/IC. Therefore, early detection of patients prone to develop BPS/IC symptoms is essential for successful therapy. We propose extended diagnostics including molecular markers. Differential diagnosis should be based on three diagnostical “columns”: (i) clinical diagnostics, (ii) histopathology, and (iii) molecular diagnostics. Analysis of molecular alterations of receptor expression in detrusor smooth muscle cells and urothelial integrity is necessary to develop patient-tailored therapeutical concepts. Although more research is needed to elucidate the pathomechanisms involved, extended BPS/IC diagnostics could already be integrated into routine patient care, allowing evidence-based pharmacotherapy of patients with idiopathic bladder overactivity and BPS/IC. Hindawi Publishing Corporation 2011 2011-10-19 /pmc/articles/PMC3199109/ /pubmed/22028706 http://dx.doi.org/10.1155/2011/639479 Text en Copyright © 2011 Jochen Neuhaus et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Neuhaus, Jochen
Schwalenberg, Thilo
Horn, Lars-Christian
Alexander, Henry
Stolzenburg, Jens-Uwe
New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis
title New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis
title_full New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis
title_fullStr New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis
title_full_unstemmed New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis
title_short New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis
title_sort new aspects in the differential diagnosis and therapy of bladder pain syndrome/interstitial cystitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199109/
https://www.ncbi.nlm.nih.gov/pubmed/22028706
http://dx.doi.org/10.1155/2011/639479
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