Cargando…

Autophagy as a Therapeutic Target in Diabetic Nephropathy

Diabetic nephropathy is a serious complication of diabetes mellitus, and its prevalence has been increasing worldwide. Therefore, there is an urgent need to identify a new therapeutic target to prevent diabetic nephropathy. Autophagy is a major catabolic pathway involved in degrading and recycling m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanaka, Yuki, Kume, Shinji, Kitada, Munehiro, Kanasaki, Keizo, Uzu, Takashi, Maegawa, Hiroshi, Koya, Daisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199112/ https://www.ncbi.nlm.nih.gov/pubmed/22028701 http://dx.doi.org/10.1155/2012/628978

Ejemplares similares

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy
por: Yamahara, Kosuke, et al.
Publicado: (2013)

Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
por: Kitada, Munehiro, et al.
Publicado: (2012)

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy
por: Kume, Shinji, et al.
Publicado: (2014)

Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy
por: Kume, Shinji, et al.
Publicado: (2015)

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes
por: Kitada, Munehiro, et al.
Publicado: (2011)

Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy
por: Kume, Shinji, et al.
Publicado: (2008)

Diabetic angiopathy and angiogenic defects
por: Xu, Ling, et al.
Publicado: (2012)

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
por: Kitada, Munehiro, et al.
Publicado: (2011)

A low-protein diet exerts a beneficial effect on diabetic status and prevents diabetic nephropathy in Wistar fatty rats, an animal model of type 2 diabetes and obesity
por: Kitada, Munehiro, et al.
Publicado: (2018)

Lipotoxicity, Nutrient-Sensing Signals, and Autophagy in Diabetic Nephropathy
por: Kume, Shinji, et al.
Publicado: (2020)

Nutrient Sensing, Autophagy, and Diabetic Nephropathy
por: Kume, Shinji, et al.
Publicado: (2012)

Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors
por: Kanasaki, Megumi, et al.
Publicado: (2011)

N-acetyl-seryl-aspartyl-lysyl-proline: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes
por: Kanasaki, Keizo, et al.
Publicado: (2014)

Predictive Effects of Urinary Liver-Type Fatty Acid–Binding Protein for Deteriorating Renal Function and Incidence of Cardiovascular Disease in Type 2 Diabetic Patients Without Advanced Nephropathy
por: Araki, Shin-ichi, et al.
Publicado: (2013)

Rodent models of diabetic nephropathy: their utility and limitations
por: Kitada, Munehiro, et al.
Publicado: (2016)

Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice
por: Takagaki, Yuta, et al.
Publicado: (2019)

Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats
por: Ogura, Yoshio, et al.
Publicado: (2018)

Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis
por: Kanasaki, Keizo, et al.
Publicado: (2013)

Lipid mediators in diabetic nephropathy
por: Srivastava, Swayam Prakash, et al.
Publicado: (2014)

Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen
por: Nitta, Kyoko, et al.
Publicado: (2016)

Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner
por: Kitada, Munehiro, et al.
Publicado: (2017)

MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT
por: Srivastava, Swayam Prakash, et al.
Publicado: (2013)

βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline
por: Gao, Rongfen, et al.
Publicado: (2019)

SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
por: Kitada, Munehiro, et al.
Publicado: (2013)

Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation
por: Takagi, Ayano, et al.
Publicado: (2016)

Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys
por: Srivastava, Swayam Prakash, et al.
Publicado: (2021)

N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition
por: Nagai, Takako, et al.
Publicado: (2014)

Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon
por: Kanasaki, Keizo, et al.
Publicado: (2019)

Effect of switching to teneligliptin from other dipeptidyl peptidase‐4 inhibitors on glucose control and renoprotection in type 2 diabetes patients with diabetic kidney disease
por: Kitada, Munehiro, et al.
Publicado: (2018)

Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance Through the CXCL12/CXCR4/mTOR/TGFβ Signaling Pathway in Breast Cancer Cells
por: Li, Shaolan, et al.
Publicado: (2020)

Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis
por: Srivastava, Swayam Prakash, et al.
Publicado: (2016)

SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis
por: Srivastava, Swayam Prakash, et al.
Publicado: (2018)

Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy
por: Araki, Hisazumi, et al.
Publicado: (2013)

Adenosine/adenosine type 1 receptor signaling pathway did not play dominant roles on the influence of sodium–glucose cotransporter 2 inhibitor in the kidney of bovine serum albumin‐overloaded streptozotocin‐induced diabetic mice
por: Shimada, Keiji, et al.
Publicado: (2022)

GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice
por: Yang, Xu, et al.
Publicado: (2011)

Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
por: Tsuda, Shin-ichi, et al.
Publicado: (2016)

Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high‐fat diet
por: Takagi, Susumu, et al.
Publicado: (2018)

Association Between Urinary Type IV Collagen Level and Deterioration of Renal Function in Type 2 Diabetic Patients Without Overt Proteinuria
por: Araki, Shin-ichi, et al.
Publicado: (2010)

CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology
por: Kawakita, Emi, et al.
Publicado: (2021)

Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis
por: Xu, Jing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eoeigh5esqch4csikao2skuch1