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MAP Kinases and Prostate Cancer

The three major mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK are signal transducers involved in a broad range of cell functions including survival, apoptosis, and cell differentiation. Whereas JNK and p38 have been generally linked to cell death and tumor suppression, ERK plays a prom...

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Autores principales: Rodríguez-Berriguete, Gonzalo, Fraile, Benito, Martínez-Onsurbe, Pilar, Olmedilla, Gabriel, Paniagua, Ricardo, Royuela, Mar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199183/
https://www.ncbi.nlm.nih.gov/pubmed/22046506
http://dx.doi.org/10.1155/2012/169170
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author Rodríguez-Berriguete, Gonzalo
Fraile, Benito
Martínez-Onsurbe, Pilar
Olmedilla, Gabriel
Paniagua, Ricardo
Royuela, Mar
author_facet Rodríguez-Berriguete, Gonzalo
Fraile, Benito
Martínez-Onsurbe, Pilar
Olmedilla, Gabriel
Paniagua, Ricardo
Royuela, Mar
author_sort Rodríguez-Berriguete, Gonzalo
collection PubMed
description The three major mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK are signal transducers involved in a broad range of cell functions including survival, apoptosis, and cell differentiation. Whereas JNK and p38 have been generally linked to cell death and tumor suppression, ERK plays a prominent role in cell survival and tumor promotion, in response to a broad range of stimuli such as cytokines, growth factors, ultraviolet radiation, hypoxia, or pharmacological compounds. However, there is a growing body of evidence supporting that JNK and p38 also contribute to the development of a number of malignances. In this paper we focus on the involvement of the MAPK pathways in prostate cancer, including the less-known ERK5 pathway, as pro- or antitumor mediators, through their effects on apoptosis, survival, metastatic potential, and androgen-independent growth.
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spelling pubmed-31991832011-11-01 MAP Kinases and Prostate Cancer Rodríguez-Berriguete, Gonzalo Fraile, Benito Martínez-Onsurbe, Pilar Olmedilla, Gabriel Paniagua, Ricardo Royuela, Mar J Signal Transduct Review Article The three major mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK are signal transducers involved in a broad range of cell functions including survival, apoptosis, and cell differentiation. Whereas JNK and p38 have been generally linked to cell death and tumor suppression, ERK plays a prominent role in cell survival and tumor promotion, in response to a broad range of stimuli such as cytokines, growth factors, ultraviolet radiation, hypoxia, or pharmacological compounds. However, there is a growing body of evidence supporting that JNK and p38 also contribute to the development of a number of malignances. In this paper we focus on the involvement of the MAPK pathways in prostate cancer, including the less-known ERK5 pathway, as pro- or antitumor mediators, through their effects on apoptosis, survival, metastatic potential, and androgen-independent growth. Hindawi Publishing Corporation 2012 2011-10-20 /pmc/articles/PMC3199183/ /pubmed/22046506 http://dx.doi.org/10.1155/2012/169170 Text en Copyright © 2012 Gonzalo Rodríguez-Berriguete et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rodríguez-Berriguete, Gonzalo
Fraile, Benito
Martínez-Onsurbe, Pilar
Olmedilla, Gabriel
Paniagua, Ricardo
Royuela, Mar
MAP Kinases and Prostate Cancer
title MAP Kinases and Prostate Cancer
title_full MAP Kinases and Prostate Cancer
title_fullStr MAP Kinases and Prostate Cancer
title_full_unstemmed MAP Kinases and Prostate Cancer
title_short MAP Kinases and Prostate Cancer
title_sort map kinases and prostate cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199183/
https://www.ncbi.nlm.nih.gov/pubmed/22046506
http://dx.doi.org/10.1155/2012/169170
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