Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate

BACKGROUND: Cancer gene therapy by retroviral vectors is mainly limited by the level of transduction. Retroviral gene transfer requires target cell division. Cell synchronization, obtained by drugs inducing a reversible inhibition of DNA synthesis, could therefore be proposed to precondition target...

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Detalles Bibliográficos
Autores principales: Finzi, Laetitia, Kraemer, Aurore, Capron, Claude, Noullet, Severine, Goere, Diane, Penna, Christophe, Nordlinger, Bernard, Legagneux, Josette, Emile, Jean-Fançois, Malafosse, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199255/
https://www.ncbi.nlm.nih.gov/pubmed/21970612
http://dx.doi.org/10.1186/1756-9966-30-92

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