CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2

BACKGROUND: Elucidating the pattern of evolutionary changes in drug-metabolizing genes is an important subject not only for evolutionary but for biomedical research. We investigated the pattern of divergence and polymorphisms of macaque CYP1A1 and CYP1A2 genes, which are major drug-metabolizing gene...

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Detalles Bibliográficos
Autores principales: Uno, Yasuhiro, Osada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199271/
https://www.ncbi.nlm.nih.gov/pubmed/21961956
http://dx.doi.org/10.1186/1471-2148-11-283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199271/
https://www.ncbi.nlm.nih.gov/pubmed/21961956
http://dx.doi.org/10.1186/1471-2148-11-283

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