Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity

The bacterium Myxococcus xanthus uses a G protein cycle to dynamically regulate the leading/lagging pole polarity axis. The G protein MglA is regulated by its GTPase-activating protein (GAP) MglB, thus resembling Ras family proteins. Here, we show structurally and biochemically that MglA undergoes a...

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Detalles Bibliográficos
Autores principales: Miertzschke, Mandy, Koerner, Carolin, Vetter, Ingrid R, Keilberg, Daniela, Hot, Edina, Leonardy, Simone, Søgaard-Andersen, Lotte, Wittinghofer, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199381/
https://www.ncbi.nlm.nih.gov/pubmed/21847100
http://dx.doi.org/10.1038/emboj.2011.291

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