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Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and to suppress growth of human cancer xenografts in vivo. However, its direct targets rema...

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Detalles Bibliográficos
Autores principales:	Polier, G, Ding, J, Konkimalla, B V, Eick, D, Ribeiro, N, Köhler, R, Giaisi, M, Efferth, T, Desaubry, L, Krammer, P H, Li-Weber, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199715/ https://www.ncbi.nlm.nih.gov/pubmed/21776020 http://dx.doi.org/10.1038/cddis.2011.66

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