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The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia
Movement disorders in Parkinson’s disease (PD) are commonly associated with slow oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural mechanisms underlying this dynamic network dysfunction, however, are only poorly understood. Here, we show that the strength of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199726/ https://www.ncbi.nlm.nih.gov/pubmed/22028684 http://dx.doi.org/10.3389/fnsys.2011.00086 |
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author | Kumar, Arvind Cardanobile, Stefano Rotter, Stefan Aertsen, Ad |
author_facet | Kumar, Arvind Cardanobile, Stefano Rotter, Stefan Aertsen, Ad |
author_sort | Kumar, Arvind |
collection | PubMed |
description | Movement disorders in Parkinson’s disease (PD) are commonly associated with slow oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural mechanisms underlying this dynamic network dysfunction, however, are only poorly understood. Here, we show that the strength of inhibitory inputs from striatum to globus pallidus external (GPe) is a key parameter controlling oscillations in the basal ganglia. Specifically, the increase in striatal activity observed in PD is sufficient to unleash the oscillations in the basal ganglia. This finding allows us to propose a unified explanation for different phenomena: absence of oscillation in the healthy state of the basal ganglia, oscillations in dopamine-depleted state and quenching of oscillations under deep-brain-stimulation (DBS). These novel insights help us to better understand and optimize the function of DBS protocols. Furthermore, studying the model behavior under transient increase of activity of the striatal neurons projecting to the indirect pathway, we are able to account for both motor impairment in PD patients and for reduced response inhibition in DBS implanted patients. |
format | Online Article Text |
id | pubmed-3199726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31997262011-10-25 The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia Kumar, Arvind Cardanobile, Stefano Rotter, Stefan Aertsen, Ad Front Syst Neurosci Neuroscience Movement disorders in Parkinson’s disease (PD) are commonly associated with slow oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural mechanisms underlying this dynamic network dysfunction, however, are only poorly understood. Here, we show that the strength of inhibitory inputs from striatum to globus pallidus external (GPe) is a key parameter controlling oscillations in the basal ganglia. Specifically, the increase in striatal activity observed in PD is sufficient to unleash the oscillations in the basal ganglia. This finding allows us to propose a unified explanation for different phenomena: absence of oscillation in the healthy state of the basal ganglia, oscillations in dopamine-depleted state and quenching of oscillations under deep-brain-stimulation (DBS). These novel insights help us to better understand and optimize the function of DBS protocols. Furthermore, studying the model behavior under transient increase of activity of the striatal neurons projecting to the indirect pathway, we are able to account for both motor impairment in PD patients and for reduced response inhibition in DBS implanted patients. Frontiers Research Foundation 2011-10-24 /pmc/articles/PMC3199726/ /pubmed/22028684 http://dx.doi.org/10.3389/fnsys.2011.00086 Text en Copyright © 2011 Kumar, Cardanobile, Rotter and Aertsen. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Neuroscience Kumar, Arvind Cardanobile, Stefano Rotter, Stefan Aertsen, Ad The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia |
title | The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia |
title_full | The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia |
title_fullStr | The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia |
title_full_unstemmed | The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia |
title_short | The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia |
title_sort | role of inhibition in generating and controlling parkinson’s disease oscillations in the basal ganglia |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199726/ https://www.ncbi.nlm.nih.gov/pubmed/22028684 http://dx.doi.org/10.3389/fnsys.2011.00086 |
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