Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

BACKGROUND: RC-101, a cationic peptide retrocyclin analog, has in vitro activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation or biological fluids in the body, this can affect product efficacy. We aime...

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Detalles Bibliográficos
Autores principales: Sassi, Alexandra B, Bunge, Katherine E, Hood, Brian L, Conrads, Thomas P, Cole, Alexander M, Gupta, Phalguni, Rohan, Lisa C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199744/
https://www.ncbi.nlm.nih.gov/pubmed/21801426
http://dx.doi.org/10.1186/1742-6405-8-27

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