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Current aspects of hearing loss from occupational and leisure noise

Hearing loss from occupational and leisure noise numbers amongst the most frequent causes of an acquired sensorineural hearing loss. Here we present a review of up-to-date findings on the pathophysiology of acoustic injury to the inner ear, with special attention being paid to its molecular-biologic...

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Autores principales: Plontke, S., Zenner, H.-P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199798/
https://www.ncbi.nlm.nih.gov/pubmed/22073048
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author Plontke, S.
Zenner, H.-P.
author_facet Plontke, S.
Zenner, H.-P.
author_sort Plontke, S.
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description Hearing loss from occupational and leisure noise numbers amongst the most frequent causes of an acquired sensorineural hearing loss. Here we present a review of up-to-date findings on the pathophysiology of acoustic injury to the inner ear, with special attention being paid to its molecular-biological and genetic aspects. Epidemiological aspects shall also be dealt with, as shall the roles of lacking recovery from occupational noise due to additional exposure by leisure noise and the combined exposure of noise and chemicals. Based on the epidemiological and pathophysiological findings and against the background of published animal-experimental, pre-clinical and clinical findings, the various approaches for prevention, protection and therapeutic intervention with acoustic trauma are discussed. Pharmacological strategies involving anti-oxidative, anti-excitotoxic and anti-apoptotic substances as well as non-pharmacological strategies like "sound conditioning" are given attention. Furthermore, systemic and local substance application as well as the therapy of acute acoustic trauma and chronic hearing problems (including modern therapy forms for comorbidities such as tinnitus) shall be delved into.
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spelling pubmed-31997982011-11-09 Current aspects of hearing loss from occupational and leisure noise Plontke, S. Zenner, H.-P. GMS Curr Top Otorhinolaryngol Head Neck Surg Article Hearing loss from occupational and leisure noise numbers amongst the most frequent causes of an acquired sensorineural hearing loss. Here we present a review of up-to-date findings on the pathophysiology of acoustic injury to the inner ear, with special attention being paid to its molecular-biological and genetic aspects. Epidemiological aspects shall also be dealt with, as shall the roles of lacking recovery from occupational noise due to additional exposure by leisure noise and the combined exposure of noise and chemicals. Based on the epidemiological and pathophysiological findings and against the background of published animal-experimental, pre-clinical and clinical findings, the various approaches for prevention, protection and therapeutic intervention with acoustic trauma are discussed. Pharmacological strategies involving anti-oxidative, anti-excitotoxic and anti-apoptotic substances as well as non-pharmacological strategies like "sound conditioning" are given attention. Furthermore, systemic and local substance application as well as the therapy of acute acoustic trauma and chronic hearing problems (including modern therapy forms for comorbidities such as tinnitus) shall be delved into. German Medical Science 2004-12-28 /pmc/articles/PMC3199798/ /pubmed/22073048 Text en Copyright © 2004 Plontke et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Article
Plontke, S.
Zenner, H.-P.
Current aspects of hearing loss from occupational and leisure noise
title Current aspects of hearing loss from occupational and leisure noise
title_full Current aspects of hearing loss from occupational and leisure noise
title_fullStr Current aspects of hearing loss from occupational and leisure noise
title_full_unstemmed Current aspects of hearing loss from occupational and leisure noise
title_short Current aspects of hearing loss from occupational and leisure noise
title_sort current aspects of hearing loss from occupational and leisure noise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199798/
https://www.ncbi.nlm.nih.gov/pubmed/22073048
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