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Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis
Restless legs syndrome is common in patients with multiple sclerosis but has not been reported as occurring due to an acute, inflammatory, demyelinating attack. Restless legs syndrome is known to be related to low brain iron levels. Multiple sclerosis has been associated with the abnormal accumulati...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199912/ https://www.ncbi.nlm.nih.gov/pubmed/22096645 http://dx.doi.org/10.1155/2011/872948 |
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author | Bernheimer, James H. |
author_facet | Bernheimer, James H. |
author_sort | Bernheimer, James H. |
collection | PubMed |
description | Restless legs syndrome is common in patients with multiple sclerosis but has not been reported as occurring due to an acute, inflammatory, demyelinating attack. Restless legs syndrome is known to be related to low brain iron levels. Multiple sclerosis has been associated with the abnormal accumulation of iron in the chronic, progressive phase of axonal degeneration. Iron deficiency may play a role in demyelination. This suggests that restless legs syndrome may be caused by the inflammatory, demyelinating component of multiple sclerosis rather than axonal degeneration. The author presents a case of self-limited restless legs syndrome occurring as an acute attack of multiple sclerosis, supporting the notion that inflammatory demyelination is the underlying pathophysiology of restless legs syndrome in multiple sclerosis. |
format | Online Article Text |
id | pubmed-3199912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31999122011-11-17 Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis Bernheimer, James H. Mult Scler Int Case Report Restless legs syndrome is common in patients with multiple sclerosis but has not been reported as occurring due to an acute, inflammatory, demyelinating attack. Restless legs syndrome is known to be related to low brain iron levels. Multiple sclerosis has been associated with the abnormal accumulation of iron in the chronic, progressive phase of axonal degeneration. Iron deficiency may play a role in demyelination. This suggests that restless legs syndrome may be caused by the inflammatory, demyelinating component of multiple sclerosis rather than axonal degeneration. The author presents a case of self-limited restless legs syndrome occurring as an acute attack of multiple sclerosis, supporting the notion that inflammatory demyelination is the underlying pathophysiology of restless legs syndrome in multiple sclerosis. Hindawi Publishing Corporation 2011 2011-07-05 /pmc/articles/PMC3199912/ /pubmed/22096645 http://dx.doi.org/10.1155/2011/872948 Text en Copyright © 2011 James H. Bernheimer. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bernheimer, James H. Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis |
title | Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis |
title_full | Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis |
title_fullStr | Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis |
title_full_unstemmed | Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis |
title_short | Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis |
title_sort | restless legs syndrome presenting as an acute exacerbation of multiple sclerosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199912/ https://www.ncbi.nlm.nih.gov/pubmed/22096645 http://dx.doi.org/10.1155/2011/872948 |
work_keys_str_mv | AT bernheimerjamesh restlesslegssyndromepresentingasanacuteexacerbationofmultiplesclerosis |