B-Cell Pathology in Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases ha...

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Detalles Bibliográficos
Autores principales: Wiegering, V., Girschick, H. J., Morbach, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199973/
https://www.ncbi.nlm.nih.gov/pubmed/22076178
http://dx.doi.org/10.1155/2010/759868
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author Wiegering, V.
Girschick, H. J.
Morbach, H.
author_facet Wiegering, V.
Girschick, H. J.
Morbach, H.
author_sort Wiegering, V.
collection PubMed
description Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA.
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spelling pubmed-31999732011-11-10 B-Cell Pathology in Juvenile Idiopathic Arthritis Wiegering, V. Girschick, H. J. Morbach, H. Arthritis Review Article Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA. Hindawi Publishing Corporation 2010 2010-12-02 /pmc/articles/PMC3199973/ /pubmed/22076178 http://dx.doi.org/10.1155/2010/759868 Text en Copyright © 2010 V. Wiegering et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wiegering, V.
Girschick, H. J.
Morbach, H.
B-Cell Pathology in Juvenile Idiopathic Arthritis
title B-Cell Pathology in Juvenile Idiopathic Arthritis
title_full B-Cell Pathology in Juvenile Idiopathic Arthritis
title_fullStr B-Cell Pathology in Juvenile Idiopathic Arthritis
title_full_unstemmed B-Cell Pathology in Juvenile Idiopathic Arthritis
title_short B-Cell Pathology in Juvenile Idiopathic Arthritis
title_sort b-cell pathology in juvenile idiopathic arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199973/
https://www.ncbi.nlm.nih.gov/pubmed/22076178
http://dx.doi.org/10.1155/2010/759868
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AT girschickhj bcellpathologyinjuvenileidiopathicarthritis
AT morbachh bcellpathologyinjuvenileidiopathicarthritis

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