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Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model

Background. Hyperbaric oxygen (HBO) therapy, which is used for many conditions, may also have immunosuppressive effects and could be used for prevention or treatment of graft-versus-host disease (GvHD). If HBO is immunosuppressant, then we hypothesize that HBO therapy will delay the T-cell mediated...

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Autores principales: Gassas, Adam, Min, Weixian, Evans, A. Wayne, Carter, Susan, Sándor, George K., Grunebaum, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200007/
https://www.ncbi.nlm.nih.gov/pubmed/22046567
http://dx.doi.org/10.1155/2011/579268
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author Gassas, Adam
Min, Weixian
Evans, A. Wayne
Carter, Susan
Sándor, George K.
Grunebaum, Eyal
author_facet Gassas, Adam
Min, Weixian
Evans, A. Wayne
Carter, Susan
Sándor, George K.
Grunebaum, Eyal
author_sort Gassas, Adam
collection PubMed
description Background. Hyperbaric oxygen (HBO) therapy, which is used for many conditions, may also have immunosuppressive effects and could be used for prevention or treatment of graft-versus-host disease (GvHD). If HBO is immunosuppressant, then we hypothesize that HBO therapy will delay the T-cell mediated skin graft rejection. Methods. C57/BL6 black-coated (H2B) mice received skin graft from CBA (H2D) white-coated mice. Mice were treated with either 19 session of 240 kpa oxygen or 29 session of 300 kpa oxygen, for 90 minutes. Mice were housed either 4 per cage or separately, to prevent friction and mechanical factors that may affect graft survival. Skin grafts were assessed daily. Results. There was no difference in length of graft survival between mice that received either regimens of HBO therapy and mice that did not receive HBO therapy. Conclusions. HBO therapy, as a sole agent, did not delay skin graft rejection in a highly immunogenic mouse model.
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spelling pubmed-32000072011-11-01 Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model Gassas, Adam Min, Weixian Evans, A. Wayne Carter, Susan Sándor, George K. Grunebaum, Eyal Bone Marrow Res Research Article Background. Hyperbaric oxygen (HBO) therapy, which is used for many conditions, may also have immunosuppressive effects and could be used for prevention or treatment of graft-versus-host disease (GvHD). If HBO is immunosuppressant, then we hypothesize that HBO therapy will delay the T-cell mediated skin graft rejection. Methods. C57/BL6 black-coated (H2B) mice received skin graft from CBA (H2D) white-coated mice. Mice were treated with either 19 session of 240 kpa oxygen or 29 session of 300 kpa oxygen, for 90 minutes. Mice were housed either 4 per cage or separately, to prevent friction and mechanical factors that may affect graft survival. Skin grafts were assessed daily. Results. There was no difference in length of graft survival between mice that received either regimens of HBO therapy and mice that did not receive HBO therapy. Conclusions. HBO therapy, as a sole agent, did not delay skin graft rejection in a highly immunogenic mouse model. Hindawi Publishing Corporation 2011 2010-08-03 /pmc/articles/PMC3200007/ /pubmed/22046567 http://dx.doi.org/10.1155/2011/579268 Text en Copyright © 2011 Adam Gassas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gassas, Adam
Min, Weixian
Evans, A. Wayne
Carter, Susan
Sándor, George K.
Grunebaum, Eyal
Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model
title Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model
title_full Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model
title_fullStr Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model
title_full_unstemmed Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model
title_short Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model
title_sort hyperbaric oxygen therapy as a sole agent is not immunosuppressant in a highly immunogenic mouse model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200007/
https://www.ncbi.nlm.nih.gov/pubmed/22046567
http://dx.doi.org/10.1155/2011/579268
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