Cargando…

Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy

BACKGROUND AND OBJECTIVES: Conventional diagnostic indicators cannot distinguish between disease activity and inactivity but can detect the past tissue destruction. A proper and true periodontal diagnosis is essential in order to have a rational treatment and preventive strategy and to identify site...

Descripción completa

Detalles Bibliográficos
Autores principales: Sheth, Tejal S., Verma, Sharmila J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200018/
https://www.ncbi.nlm.nih.gov/pubmed/22028510
http://dx.doi.org/10.4103/0972-124X.85666
_version_ 1782214634243096576
author Sheth, Tejal S.
Verma, Sharmila J
author_facet Sheth, Tejal S.
Verma, Sharmila J
author_sort Sheth, Tejal S.
collection PubMed
description BACKGROUND AND OBJECTIVES: Conventional diagnostic indicators cannot distinguish between disease activity and inactivity but can detect the past tissue destruction. A proper and true periodontal diagnosis is essential in order to have a rational treatment and preventive strategy and to identify sites at risk. The present longitudinal study was designed with an aim to examine the relationship between gingival crevicular fluid (GCF) levels of aspartate aminotransferase (AST) and periodontal disease progression and to analyze the level of AST in GCF before and after the initial therapy in chronic periodontitis patients and determine the relationship between AST and conventional measures of periodontal status. MATERIALS AND METHODS: A total of 20 patients with chronic periodontitis were randomly selected. Two diseased sites and one healthy site were selected in each patient. The periodontal status and GCF-AST levels were recorded at baseline and 3 months post-initial therapy and statistically analyzed. RESULTS: There was a statistically significant difference in AST levels between diseased periodontal sites and healthy sites (P<0.05), and between baseline and post-initial therapy (P<0.05). Improvements in clinical status were noted following periodontal therapy and there was a corresponding decrease in AST levels. INTERPRETATION AND CONCLUSION: In conclusion, it is suggested that AST levels may be a useful adjunct in the clinical assessment of periodontal disease sites since AST level decreases when periodontal status improves.
format Online
Article
Text
id pubmed-3200018
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-32000182011-10-25 Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy Sheth, Tejal S. Verma, Sharmila J J Indian Soc Periodontol Original Article BACKGROUND AND OBJECTIVES: Conventional diagnostic indicators cannot distinguish between disease activity and inactivity but can detect the past tissue destruction. A proper and true periodontal diagnosis is essential in order to have a rational treatment and preventive strategy and to identify sites at risk. The present longitudinal study was designed with an aim to examine the relationship between gingival crevicular fluid (GCF) levels of aspartate aminotransferase (AST) and periodontal disease progression and to analyze the level of AST in GCF before and after the initial therapy in chronic periodontitis patients and determine the relationship between AST and conventional measures of periodontal status. MATERIALS AND METHODS: A total of 20 patients with chronic periodontitis were randomly selected. Two diseased sites and one healthy site were selected in each patient. The periodontal status and GCF-AST levels were recorded at baseline and 3 months post-initial therapy and statistically analyzed. RESULTS: There was a statistically significant difference in AST levels between diseased periodontal sites and healthy sites (P<0.05), and between baseline and post-initial therapy (P<0.05). Improvements in clinical status were noted following periodontal therapy and there was a corresponding decrease in AST levels. INTERPRETATION AND CONCLUSION: In conclusion, it is suggested that AST levels may be a useful adjunct in the clinical assessment of periodontal disease sites since AST level decreases when periodontal status improves. Medknow Publications 2011 /pmc/articles/PMC3200018/ /pubmed/22028510 http://dx.doi.org/10.4103/0972-124X.85666 Text en Copyright: © Journal of Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sheth, Tejal S.
Verma, Sharmila J
Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
title Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
title_full Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
title_fullStr Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
title_full_unstemmed Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
title_short Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
title_sort analysis of aspartate aminotransferase in gingival crevicular fluid: a study with initial therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200018/
https://www.ncbi.nlm.nih.gov/pubmed/22028510
http://dx.doi.org/10.4103/0972-124X.85666
work_keys_str_mv AT shethtejals analysisofaspartateaminotransferaseingingivalcrevicularfluidastudywithinitialtherapy
AT vermasharmilaj analysisofaspartateaminotransferaseingingivalcrevicularfluidastudywithinitialtherapy