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Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients
BACKGROUND: Rheumatoid arthritis is a multi-system autoimmune disorder predominantly involving multiple small and large joints along with certain extra-articular manifestations. The presence of peripheral neuropathy in patients with rheumatoid arthritis contributes significantly to the functional li...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200043/ https://www.ncbi.nlm.nih.gov/pubmed/22028533 http://dx.doi.org/10.4103/0972-2327.85893 |
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author | Biswas, Monodeep Chatterjee, Arghya Ghosh, Sudip Kumar Dasgupta, S. Ghosh, Kartik Ganguly, P. K. |
author_facet | Biswas, Monodeep Chatterjee, Arghya Ghosh, Sudip Kumar Dasgupta, S. Ghosh, Kartik Ganguly, P. K. |
author_sort | Biswas, Monodeep |
collection | PubMed |
description | BACKGROUND: Rheumatoid arthritis is a multi-system autoimmune disorder predominantly involving multiple small and large joints along with certain extra-articular manifestations. The presence of peripheral neuropathy in patients with rheumatoid arthritis contributes significantly to the functional limitation in patients with rheumatoid arthritis. OBJECTIVES: To study the prevalence, types, and determinants of peripheral neuropathy in patients with rheumatoid arthritis. MATERIALS AND METHODS: We studied 74 patients with rheumatoid arthritis of at least 2 year duration for the presence of peripheral neuropathy both clinically and electrophysiologically. The data obtained were entered into a database and continuous variables were analyzed using the Student t test and categorical variables were analyzed using the chi-square test. RESULTS: Peripheral neuropathy was detected in 39.19% (29 out of 74 patients) patients on electrophysiologic testing and 82.76% (24 out of 29 patients) of the patients were asymptomatic. There was significant association between the presence of peripheral neuropathy and disease duration and rheumatoid factor positivity by the latex agglutination method. Sensory neuropathy was the most common form detected. CONCLUSIONS: Our study shows that subclinical peripheral neuropathy particularly sensory neuropathy which is not related to disease severity is very common in patients with prolonged disease duration. |
format | Online Article Text |
id | pubmed-3200043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-32000432011-10-25 Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients Biswas, Monodeep Chatterjee, Arghya Ghosh, Sudip Kumar Dasgupta, S. Ghosh, Kartik Ganguly, P. K. Ann Indian Acad Neurol Short Communication BACKGROUND: Rheumatoid arthritis is a multi-system autoimmune disorder predominantly involving multiple small and large joints along with certain extra-articular manifestations. The presence of peripheral neuropathy in patients with rheumatoid arthritis contributes significantly to the functional limitation in patients with rheumatoid arthritis. OBJECTIVES: To study the prevalence, types, and determinants of peripheral neuropathy in patients with rheumatoid arthritis. MATERIALS AND METHODS: We studied 74 patients with rheumatoid arthritis of at least 2 year duration for the presence of peripheral neuropathy both clinically and electrophysiologically. The data obtained were entered into a database and continuous variables were analyzed using the Student t test and categorical variables were analyzed using the chi-square test. RESULTS: Peripheral neuropathy was detected in 39.19% (29 out of 74 patients) patients on electrophysiologic testing and 82.76% (24 out of 29 patients) of the patients were asymptomatic. There was significant association between the presence of peripheral neuropathy and disease duration and rheumatoid factor positivity by the latex agglutination method. Sensory neuropathy was the most common form detected. CONCLUSIONS: Our study shows that subclinical peripheral neuropathy particularly sensory neuropathy which is not related to disease severity is very common in patients with prolonged disease duration. Medknow Publications 2011 /pmc/articles/PMC3200043/ /pubmed/22028533 http://dx.doi.org/10.4103/0972-2327.85893 Text en Copyright: © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Biswas, Monodeep Chatterjee, Arghya Ghosh, Sudip Kumar Dasgupta, S. Ghosh, Kartik Ganguly, P. K. Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients |
title | Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients |
title_full | Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients |
title_fullStr | Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients |
title_full_unstemmed | Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients |
title_short | Prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients |
title_sort | prevalence, types, clinical associations, and determinants of peripheral neuropathy in rheumatoid patients |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200043/ https://www.ncbi.nlm.nih.gov/pubmed/22028533 http://dx.doi.org/10.4103/0972-2327.85893 |
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