A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies

A 71-year-old Japanese male patient infected with HCV was diagnosed with thrombocytopenia. Histological examination of the bone marrow aspirate showed numerous lymphoid aggregates with Russell bodies. Immunohistochemistry and flow cytometric analysis demonstrated clonal expansion of CD5+ CD23+ B cel...

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Autores principales: Kayano, Hidekazu, Shimada, Tsuneyuki, Wakimoto, Naoki, Nakamura, Yuichi, Bessho, Masami, Yamaguchi, Hiroshi, Sasaki, Atsushi, Shimizu, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200063/
https://www.ncbi.nlm.nih.gov/pubmed/22046570
http://dx.doi.org/10.1155/2011/814372
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author Kayano, Hidekazu
Shimada, Tsuneyuki
Wakimoto, Naoki
Nakamura, Yuichi
Bessho, Masami
Yamaguchi, Hiroshi
Sasaki, Atsushi
Shimizu, Michio
author_facet Kayano, Hidekazu
Shimada, Tsuneyuki
Wakimoto, Naoki
Nakamura, Yuichi
Bessho, Masami
Yamaguchi, Hiroshi
Sasaki, Atsushi
Shimizu, Michio
author_sort Kayano, Hidekazu
collection PubMed
description A 71-year-old Japanese male patient infected with HCV was diagnosed with thrombocytopenia. Histological examination of the bone marrow aspirate showed numerous lymphoid aggregates with Russell bodies. Immunohistochemistry and flow cytometric analysis demonstrated clonal expansion of CD5+ CD23+ B cells. Russell bodies were positive for IgM and lambda immunoglobulin light chain. The patient also underwent gastric biopsy, which revealed Helicobacter pylori (HP) infection. Subsequent eradication of the bacteria resulted in improvement of his thrombocytopenia. The clinical course remained uneventful at 15-month follow-up, consistent with monoclonal B-cell lymphocytosis. The observed clonal expansion with plasmacytic differentiation may have occurred under the influence of HCV with HP infection.
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spelling pubmed-32000632011-11-01 A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies Kayano, Hidekazu Shimada, Tsuneyuki Wakimoto, Naoki Nakamura, Yuichi Bessho, Masami Yamaguchi, Hiroshi Sasaki, Atsushi Shimizu, Michio Bone Marrow Res Case Report A 71-year-old Japanese male patient infected with HCV was diagnosed with thrombocytopenia. Histological examination of the bone marrow aspirate showed numerous lymphoid aggregates with Russell bodies. Immunohistochemistry and flow cytometric analysis demonstrated clonal expansion of CD5+ CD23+ B cells. Russell bodies were positive for IgM and lambda immunoglobulin light chain. The patient also underwent gastric biopsy, which revealed Helicobacter pylori (HP) infection. Subsequent eradication of the bacteria resulted in improvement of his thrombocytopenia. The clinical course remained uneventful at 15-month follow-up, consistent with monoclonal B-cell lymphocytosis. The observed clonal expansion with plasmacytic differentiation may have occurred under the influence of HCV with HP infection. Hindawi Publishing Corporation 2011 2011-03-07 /pmc/articles/PMC3200063/ /pubmed/22046570 http://dx.doi.org/10.1155/2011/814372 Text en Copyright © 2011 Hidekazu Kayano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kayano, Hidekazu
Shimada, Tsuneyuki
Wakimoto, Naoki
Nakamura, Yuichi
Bessho, Masami
Yamaguchi, Hiroshi
Sasaki, Atsushi
Shimizu, Michio
A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies
title A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies
title_full A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies
title_fullStr A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies
title_full_unstemmed A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies
title_short A Case of Monoclonal Lymphoplasmacytosis of the Bone Marrow with IgM-Positive Russell Bodies
title_sort case of monoclonal lymphoplasmacytosis of the bone marrow with igm-positive russell bodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200063/
https://www.ncbi.nlm.nih.gov/pubmed/22046570
http://dx.doi.org/10.1155/2011/814372
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