Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis

We used flow cytometry to analyze the cell cycle, DNA damage, and apoptosis in hematopoietic subsets in MDS marrow. Subsets were assigned using CD45, side scatter, CD34, and CD71. Cell cycle fractions were analyzed using DRAQ 5 (DNA content) and MPM-2 (mitoses). DNA damage was assessed using p-H2A.X...

Descripción completa

Detalles Bibliográficos
Autores principales: Head, David R., Jacobberger, James W., Mosse, Claudio, Jagasia, Madan, Dupont, William, Goodman, Stacey, Flye, Leanne, Shinar, Andrew, McClintock-Treep, Sara, Stelzer, Greg, Briggs, Robert, Shults, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200066/
https://www.ncbi.nlm.nih.gov/pubmed/22046573
http://dx.doi.org/10.1155/2011/950934

Ejemplares similares

Ejemplares similares