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Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy

Sickle cell disease is one of the common hemoglobinopathies in the world. It can affect any part of the body and one of the most common and an early organ to be affected in SCA is the spleen. It is commonly enlarged during the first decade of life but then undergoes progressive atrophy leading to au...

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Autor principal: Al-Salem, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200071/
https://www.ncbi.nlm.nih.gov/pubmed/22084706
http://dx.doi.org/10.5402/2011/864257
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author Al-Salem, Ahmed H.
author_facet Al-Salem, Ahmed H.
author_sort Al-Salem, Ahmed H.
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description Sickle cell disease is one of the common hemoglobinopathies in the world. It can affect any part of the body and one of the most common and an early organ to be affected in SCA is the spleen. It is commonly enlarged during the first decade of life but then undergoes progressive atrophy leading to autosplenectomy. This however is not the case always and sometimes splenomegaly persist necessitating splenectomy for a variety of reasons including acute splenic sequestration crisis, hypersplenism, massive splenic infarction and splenic abscess. Splenic complications of SCA are known to be associated with an increased morbidity and in some it may lead to mortality. To obviate this, splenectomy becomes an essential part of their management. This review is based on our experience in the management of 173 children with various splenic complications of SCA necessitating splenectomy.
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spelling pubmed-32000712011-11-14 Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy Al-Salem, Ahmed H. ISRN Hematol Review Article Sickle cell disease is one of the common hemoglobinopathies in the world. It can affect any part of the body and one of the most common and an early organ to be affected in SCA is the spleen. It is commonly enlarged during the first decade of life but then undergoes progressive atrophy leading to autosplenectomy. This however is not the case always and sometimes splenomegaly persist necessitating splenectomy for a variety of reasons including acute splenic sequestration crisis, hypersplenism, massive splenic infarction and splenic abscess. Splenic complications of SCA are known to be associated with an increased morbidity and in some it may lead to mortality. To obviate this, splenectomy becomes an essential part of their management. This review is based on our experience in the management of 173 children with various splenic complications of SCA necessitating splenectomy. International Scholarly Research Network 2011 2010-10-31 /pmc/articles/PMC3200071/ /pubmed/22084706 http://dx.doi.org/10.5402/2011/864257 Text en Copyright © 2011 Ahmed H. Al-Salem. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Al-Salem, Ahmed H.
Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy
title Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy
title_full Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy
title_fullStr Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy
title_full_unstemmed Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy
title_short Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy
title_sort splenic complications of sickle cell anemia and the role of splenectomy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200071/
https://www.ncbi.nlm.nih.gov/pubmed/22084706
http://dx.doi.org/10.5402/2011/864257
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