Cargando…
Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum
Control of diseases inflicted by protozoan parasites such as Leishmania, Trypanosoma, and Plasmodium, which pose a serious threat to human health worldwide, depends on a rather small number of antiparasite drugs, of which many are toxic and/or inefficient. Moreover, the increasing occurrence of drug...
Autores principales: | Roy, Amit, D'Annessa, Ilda, Nielsen, Christine J. F., Tordrup, David, Laursen, Rune R., Knudsen, Birgitta Ruth, Desideri, Alessandro, Andersen, Felicie Faucon |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200115/ https://www.ncbi.nlm.nih.gov/pubmed/22091414 http://dx.doi.org/10.4061/2011/854626 |
Ejemplares similares
-
ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism
por: Sengupta, Souvik, et al.
Publicado: (2011) -
Development of Derivatives of 3, 3′-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons
por: Roy, Amit, et al.
Publicado: (2011) -
Replacement of the Human Topoisomerase Linker Domain with the Plasmodial Counterpart Renders the Enzyme Camptothecin Resistant
por: Arnò, Barbara, et al.
Publicado: (2013) -
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
por: Tesauro, Cinzia, et al.
Publicado: (2013) -
A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance
por: Losasso, Carmen, et al.
Publicado: (2008)