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Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200120/ https://www.ncbi.nlm.nih.gov/pubmed/22046513 http://dx.doi.org/10.1155/2011/203901 |
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author | Conde, Javier Scotece, Morena Gómez, Rodolfo Lopez, Veronica Gómez-Reino, Juan Jesus Gualillo, Oreste |
author_facet | Conde, Javier Scotece, Morena Gómez, Rodolfo Lopez, Veronica Gómez-Reino, Juan Jesus Gualillo, Oreste |
author_sort | Conde, Javier |
collection | PubMed |
description | Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases. |
format | Online Article Text |
id | pubmed-3200120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32001202011-11-01 Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease Conde, Javier Scotece, Morena Gómez, Rodolfo Lopez, Veronica Gómez-Reino, Juan Jesus Gualillo, Oreste Arthritis Review Article Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases. Hindawi Publishing Corporation 2011 2011-08-18 /pmc/articles/PMC3200120/ /pubmed/22046513 http://dx.doi.org/10.1155/2011/203901 Text en Copyright © 2011 Javier Conde et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Conde, Javier Scotece, Morena Gómez, Rodolfo Lopez, Veronica Gómez-Reino, Juan Jesus Gualillo, Oreste Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease |
title | Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease |
title_full | Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease |
title_fullStr | Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease |
title_full_unstemmed | Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease |
title_short | Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease |
title_sort | adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200120/ https://www.ncbi.nlm.nih.gov/pubmed/22046513 http://dx.doi.org/10.1155/2011/203901 |
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