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Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease

Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fa...

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Detalles Bibliográficos
Autores principales: Conde, Javier, Scotece, Morena, Gómez, Rodolfo, Lopez, Veronica, Gómez-Reino, Juan Jesus, Gualillo, Oreste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200120/
https://www.ncbi.nlm.nih.gov/pubmed/22046513
http://dx.doi.org/10.1155/2011/203901
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author Conde, Javier
Scotece, Morena
Gómez, Rodolfo
Lopez, Veronica
Gómez-Reino, Juan Jesus
Gualillo, Oreste
author_facet Conde, Javier
Scotece, Morena
Gómez, Rodolfo
Lopez, Veronica
Gómez-Reino, Juan Jesus
Gualillo, Oreste
author_sort Conde, Javier
collection PubMed
description Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases.
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spelling pubmed-32001202011-11-01 Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease Conde, Javier Scotece, Morena Gómez, Rodolfo Lopez, Veronica Gómez-Reino, Juan Jesus Gualillo, Oreste Arthritis Review Article Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases. Hindawi Publishing Corporation 2011 2011-08-18 /pmc/articles/PMC3200120/ /pubmed/22046513 http://dx.doi.org/10.1155/2011/203901 Text en Copyright © 2011 Javier Conde et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Conde, Javier
Scotece, Morena
Gómez, Rodolfo
Lopez, Veronica
Gómez-Reino, Juan Jesus
Gualillo, Oreste
Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
title Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
title_full Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
title_fullStr Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
title_full_unstemmed Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
title_short Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
title_sort adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200120/
https://www.ncbi.nlm.nih.gov/pubmed/22046513
http://dx.doi.org/10.1155/2011/203901
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