Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome

A positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with a...

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Detalles Bibliográficos
Autores principales: Iczkowski, Kenneth A., Lucia, M. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200270/
https://www.ncbi.nlm.nih.gov/pubmed/22110996
http://dx.doi.org/10.1155/2011/673021
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author Iczkowski, Kenneth A.
Lucia, M. Scott
author_facet Iczkowski, Kenneth A.
Lucia, M. Scott
author_sort Iczkowski, Kenneth A.
collection PubMed
description A positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with a doubled or tripled risk of failure. The effect of a positive margin on outcome can be modified by stage or grade and the length, number and location of positive margins, as well as by technical operative approach and duration of operator experience. This paper tabulates data from the past decade of studies on margin status.
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spelling pubmed-32002702011-11-22 Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome Iczkowski, Kenneth A. Lucia, M. Scott Prostate Cancer Review Article A positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with a doubled or tripled risk of failure. The effect of a positive margin on outcome can be modified by stage or grade and the length, number and location of positive margins, as well as by technical operative approach and duration of operator experience. This paper tabulates data from the past decade of studies on margin status. Hindawi Publishing Corporation 2011 2011-06-09 /pmc/articles/PMC3200270/ /pubmed/22110996 http://dx.doi.org/10.1155/2011/673021 Text en Copyright © 2011 K. A. Iczkowski and M. S. Lucia. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Iczkowski, Kenneth A.
Lucia, M. Scott
Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome
title Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome
title_full Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome
title_fullStr Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome
title_full_unstemmed Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome
title_short Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome
title_sort frequency of positive surgical margin at prostatectomy and its effect on patient outcome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200270/
https://www.ncbi.nlm.nih.gov/pubmed/22110996
http://dx.doi.org/10.1155/2011/673021
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