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Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study

Background. Transrectal prostate biopsy is the standard protocol for the screening for prostate cancer. It helps to locate prostatic adenocarcinoma and plan treatment. However, the increasing number of prostate biopsies leads to considerably greater costs for the pathology laboratories. In this stud...

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Autores principales: Parada, David, Calvo, Nahum, Peña, Karla, Morente, Vanesa, Queralt, Rosana, Hernandez, Pilar, Riu, Francesc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200289/
https://www.ncbi.nlm.nih.gov/pubmed/22096657
http://dx.doi.org/10.1155/2011/380249
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author Parada, David
Calvo, Nahum
Peña, Karla
Morente, Vanesa
Queralt, Rosana
Hernandez, Pilar
Riu, Francesc
author_facet Parada, David
Calvo, Nahum
Peña, Karla
Morente, Vanesa
Queralt, Rosana
Hernandez, Pilar
Riu, Francesc
author_sort Parada, David
collection PubMed
description Background. Transrectal prostate biopsy is the standard protocol for the screening for prostate cancer. It helps to locate prostatic adenocarcinoma and plan treatment. However, the increasing number of prostate biopsies leads to considerably greater costs for the pathology laboratories. In this study, we compare the traditional method with an ink method in combination with a systematic histopathologic protocol. Methods. Two hundred consecutive transrectal prostate biopsy specimens were received from the radiology department. They were separated into two groups: one hundred were processed as six different specimens in the usual manner. The other one hundred were submitted in six containers, the apex, base, and middle section of which were stained different colours. The samples subject to the ink method were embedded in paraffin and placed in two cassettes which were sectioned using a specific protocol. Results. The comparative study of the nonink and ink methods for histopathologic diagnosis showed no statistical differences as far as diagnostic categories were concerned (P  value < .005). The number of PIN diagnoses increased when the ink method was used, but no statistical differences were found. The ink method led to a cost reduction of 48.86%. Conclusions. Our ink method combined with a specific histopathologic protocol provided the same diagnostic quality, tumor location information as the traditional method, and lower pathology expenses.
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spelling pubmed-32002892011-11-17 Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study Parada, David Calvo, Nahum Peña, Karla Morente, Vanesa Queralt, Rosana Hernandez, Pilar Riu, Francesc Prostate Cancer Research Article Background. Transrectal prostate biopsy is the standard protocol for the screening for prostate cancer. It helps to locate prostatic adenocarcinoma and plan treatment. However, the increasing number of prostate biopsies leads to considerably greater costs for the pathology laboratories. In this study, we compare the traditional method with an ink method in combination with a systematic histopathologic protocol. Methods. Two hundred consecutive transrectal prostate biopsy specimens were received from the radiology department. They were separated into two groups: one hundred were processed as six different specimens in the usual manner. The other one hundred were submitted in six containers, the apex, base, and middle section of which were stained different colours. The samples subject to the ink method were embedded in paraffin and placed in two cassettes which were sectioned using a specific protocol. Results. The comparative study of the nonink and ink methods for histopathologic diagnosis showed no statistical differences as far as diagnostic categories were concerned (P  value < .005). The number of PIN diagnoses increased when the ink method was used, but no statistical differences were found. The ink method led to a cost reduction of 48.86%. Conclusions. Our ink method combined with a specific histopathologic protocol provided the same diagnostic quality, tumor location information as the traditional method, and lower pathology expenses. Hindawi Publishing Corporation 2011 2011-06-09 /pmc/articles/PMC3200289/ /pubmed/22096657 http://dx.doi.org/10.1155/2011/380249 Text en Copyright © 2011 David Parada et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Parada, David
Calvo, Nahum
Peña, Karla
Morente, Vanesa
Queralt, Rosana
Hernandez, Pilar
Riu, Francesc
Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study
title Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study
title_full Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study
title_fullStr Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study
title_full_unstemmed Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study
title_short Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study
title_sort systematic analysis of transrectal prostate biopsies using an ink method and specific histopathologic protocol: a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200289/
https://www.ncbi.nlm.nih.gov/pubmed/22096657
http://dx.doi.org/10.1155/2011/380249
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