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Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome

We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures (OR = 5.89, P < .0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The cur...

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Autores principales: Iczkowski, Kenneth A., Torkko, Kathleen C., Kotnis, Gregory R., Wilson, R. Storey, Huang, Wei, Wheeler, Thomas M., Abeyta, Andrea M., Lucia, M. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200296/
https://www.ncbi.nlm.nih.gov/pubmed/22110997
http://dx.doi.org/10.1155/2011/693853
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author Iczkowski, Kenneth A.
Torkko, Kathleen C.
Kotnis, Gregory R.
Wilson, R. Storey
Huang, Wei
Wheeler, Thomas M.
Abeyta, Andrea M.
Lucia, M. Scott
author_facet Iczkowski, Kenneth A.
Torkko, Kathleen C.
Kotnis, Gregory R.
Wilson, R. Storey
Huang, Wei
Wheeler, Thomas M.
Abeyta, Andrea M.
Lucia, M. Scott
author_sort Iczkowski, Kenneth A.
collection PubMed
description We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures (OR = 5.89, P < .0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The current study's hypothesis: pseudolumen size and shape variability could stratify outcome within histologic patterns (single separate acini, separate acini with undulating lumens, fused small acini, papillary, cribriform). Pseudolumens were filled digitally on image captures from previously annotated specimens. Among all 5 patterns, pseudolumen spaces averaged smaller in failures than nonfailures. After multivariate analysis controlling for stage, age, margin, cancer amount, prostate volume, and presence of individual cells (grade 5), this retained significance only for the undulating-lumens and papillary patterns. In undulating-lumens pattern, PSA failures had smaller mean pseudolumen space sizes (P = .03) but larger perimeters (P = .04), implying more pseudolumen irregularity. In papillary pattern, the number of pseudolumen spaces was higher in failures (P = .015), space size was smaller (P = .11), perimeters were smaller (P = .04), and perimeter/size ratio was higher (P = .02). In conclusion, digitally measured pseudolumen size and shape may associate with outcome.
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spelling pubmed-32002962011-11-22 Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome Iczkowski, Kenneth A. Torkko, Kathleen C. Kotnis, Gregory R. Wilson, R. Storey Huang, Wei Wheeler, Thomas M. Abeyta, Andrea M. Lucia, M. Scott Prostate Cancer Research Article We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures (OR = 5.89, P < .0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The current study's hypothesis: pseudolumen size and shape variability could stratify outcome within histologic patterns (single separate acini, separate acini with undulating lumens, fused small acini, papillary, cribriform). Pseudolumens were filled digitally on image captures from previously annotated specimens. Among all 5 patterns, pseudolumen spaces averaged smaller in failures than nonfailures. After multivariate analysis controlling for stage, age, margin, cancer amount, prostate volume, and presence of individual cells (grade 5), this retained significance only for the undulating-lumens and papillary patterns. In undulating-lumens pattern, PSA failures had smaller mean pseudolumen space sizes (P = .03) but larger perimeters (P = .04), implying more pseudolumen irregularity. In papillary pattern, the number of pseudolumen spaces was higher in failures (P = .015), space size was smaller (P = .11), perimeters were smaller (P = .04), and perimeter/size ratio was higher (P = .02). In conclusion, digitally measured pseudolumen size and shape may associate with outcome. Hindawi Publishing Corporation 2011 2011-07-14 /pmc/articles/PMC3200296/ /pubmed/22110997 http://dx.doi.org/10.1155/2011/693853 Text en Copyright © 2011 Kenneth A. Iczkowski et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Iczkowski, Kenneth A.
Torkko, Kathleen C.
Kotnis, Gregory R.
Wilson, R. Storey
Huang, Wei
Wheeler, Thomas M.
Abeyta, Andrea M.
Lucia, M. Scott
Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
title Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
title_full Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
title_fullStr Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
title_full_unstemmed Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
title_short Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
title_sort pseudolumen size and perimeter in prostate cancer: correlation with patient outcome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200296/
https://www.ncbi.nlm.nih.gov/pubmed/22110997
http://dx.doi.org/10.1155/2011/693853
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