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Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures (OR = 5.89, P < .0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The cur...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200296/ https://www.ncbi.nlm.nih.gov/pubmed/22110997 http://dx.doi.org/10.1155/2011/693853 |
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author | Iczkowski, Kenneth A. Torkko, Kathleen C. Kotnis, Gregory R. Wilson, R. Storey Huang, Wei Wheeler, Thomas M. Abeyta, Andrea M. Lucia, M. Scott |
author_facet | Iczkowski, Kenneth A. Torkko, Kathleen C. Kotnis, Gregory R. Wilson, R. Storey Huang, Wei Wheeler, Thomas M. Abeyta, Andrea M. Lucia, M. Scott |
author_sort | Iczkowski, Kenneth A. |
collection | PubMed |
description | We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures (OR = 5.89, P < .0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The current study's hypothesis: pseudolumen size and shape variability could stratify outcome within histologic patterns (single separate acini, separate acini with undulating lumens, fused small acini, papillary, cribriform). Pseudolumens were filled digitally on image captures from previously annotated specimens. Among all 5 patterns, pseudolumen spaces averaged smaller in failures than nonfailures. After multivariate analysis controlling for stage, age, margin, cancer amount, prostate volume, and presence of individual cells (grade 5), this retained significance only for the undulating-lumens and papillary patterns. In undulating-lumens pattern, PSA failures had smaller mean pseudolumen space sizes (P = .03) but larger perimeters (P = .04), implying more pseudolumen irregularity. In papillary pattern, the number of pseudolumen spaces was higher in failures (P = .015), space size was smaller (P = .11), perimeters were smaller (P = .04), and perimeter/size ratio was higher (P = .02). In conclusion, digitally measured pseudolumen size and shape may associate with outcome. |
format | Online Article Text |
id | pubmed-3200296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32002962011-11-22 Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome Iczkowski, Kenneth A. Torkko, Kathleen C. Kotnis, Gregory R. Wilson, R. Storey Huang, Wei Wheeler, Thomas M. Abeyta, Andrea M. Lucia, M. Scott Prostate Cancer Research Article We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures (OR = 5.89, P < .0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The current study's hypothesis: pseudolumen size and shape variability could stratify outcome within histologic patterns (single separate acini, separate acini with undulating lumens, fused small acini, papillary, cribriform). Pseudolumens were filled digitally on image captures from previously annotated specimens. Among all 5 patterns, pseudolumen spaces averaged smaller in failures than nonfailures. After multivariate analysis controlling for stage, age, margin, cancer amount, prostate volume, and presence of individual cells (grade 5), this retained significance only for the undulating-lumens and papillary patterns. In undulating-lumens pattern, PSA failures had smaller mean pseudolumen space sizes (P = .03) but larger perimeters (P = .04), implying more pseudolumen irregularity. In papillary pattern, the number of pseudolumen spaces was higher in failures (P = .015), space size was smaller (P = .11), perimeters were smaller (P = .04), and perimeter/size ratio was higher (P = .02). In conclusion, digitally measured pseudolumen size and shape may associate with outcome. Hindawi Publishing Corporation 2011 2011-07-14 /pmc/articles/PMC3200296/ /pubmed/22110997 http://dx.doi.org/10.1155/2011/693853 Text en Copyright © 2011 Kenneth A. Iczkowski et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Iczkowski, Kenneth A. Torkko, Kathleen C. Kotnis, Gregory R. Wilson, R. Storey Huang, Wei Wheeler, Thomas M. Abeyta, Andrea M. Lucia, M. Scott Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
title | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
title_full | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
title_fullStr | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
title_full_unstemmed | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
title_short | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
title_sort | pseudolumen size and perimeter in prostate cancer: correlation with patient outcome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200296/ https://www.ncbi.nlm.nih.gov/pubmed/22110997 http://dx.doi.org/10.1155/2011/693853 |
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