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Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms

We previously found that gender influenced the JAK2 V617F allele burden, but it is unknown whether this gender difference in molecular epidemiology influences complications in the myeloproliferative neoplasms (MPNs). Historically, vascular complications represented the most common cause of mortality...

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Autores principales: Stein, Brady L., Rademaker, Alfred, Spivak, Jerry L., Moliterno, Alison R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200304/
https://www.ncbi.nlm.nih.gov/pubmed/22084670
http://dx.doi.org/10.1155/2011/874146
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author Stein, Brady L.
Rademaker, Alfred
Spivak, Jerry L.
Moliterno, Alison R.
author_facet Stein, Brady L.
Rademaker, Alfred
Spivak, Jerry L.
Moliterno, Alison R.
author_sort Stein, Brady L.
collection PubMed
description We previously found that gender influenced the JAK2 V617F allele burden, but it is unknown whether this gender difference in molecular epidemiology influences complications in the myeloproliferative neoplasms (MPNs). Historically, vascular complications represented the most common cause of mortality in polycythemia vera and essential thrombocytosis and contributed to morbidity in primary myelofibrosis. To determine the influence of gender on vascular complications, we retrospectively analyzed associations between gender and vascular complications. Despite their younger age, less prevalent dyslipidemia or smoking history, lower white blood counts, and lower JAK2 V617F allele burden, women had higher rates of abdominal venous thrombosis and comparable rates of all vascular complications. Vascular risk is currently not easily stratified by MPN-disease burden or traditional risk factors. Our analysis contributes to growing literature emphasizing gender differences in the MPN and further supports the important impact of individual and host variation on MPN clinical manifestations, and especially vascular risk.
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spelling pubmed-32003042011-11-14 Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms Stein, Brady L. Rademaker, Alfred Spivak, Jerry L. Moliterno, Alison R. Thrombosis Research Article We previously found that gender influenced the JAK2 V617F allele burden, but it is unknown whether this gender difference in molecular epidemiology influences complications in the myeloproliferative neoplasms (MPNs). Historically, vascular complications represented the most common cause of mortality in polycythemia vera and essential thrombocytosis and contributed to morbidity in primary myelofibrosis. To determine the influence of gender on vascular complications, we retrospectively analyzed associations between gender and vascular complications. Despite their younger age, less prevalent dyslipidemia or smoking history, lower white blood counts, and lower JAK2 V617F allele burden, women had higher rates of abdominal venous thrombosis and comparable rates of all vascular complications. Vascular risk is currently not easily stratified by MPN-disease burden or traditional risk factors. Our analysis contributes to growing literature emphasizing gender differences in the MPN and further supports the important impact of individual and host variation on MPN clinical manifestations, and especially vascular risk. Hindawi Publishing Corporation 2011 2011-07-24 /pmc/articles/PMC3200304/ /pubmed/22084670 http://dx.doi.org/10.1155/2011/874146 Text en Copyright © 2011 Brady L. Stein et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Stein, Brady L.
Rademaker, Alfred
Spivak, Jerry L.
Moliterno, Alison R.
Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms
title Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms
title_full Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms
title_fullStr Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms
title_full_unstemmed Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms
title_short Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms
title_sort gender and vascular complications in the jak2 v617f-positive myeloproliferative neoplasms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200304/
https://www.ncbi.nlm.nih.gov/pubmed/22084670
http://dx.doi.org/10.1155/2011/874146
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