Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism

BACKGROUND: Celecoxib (Celebrex), a widely prescribed selective inhibitor of cyclooxygenase-2, can modulate ion channels independently of cyclooxygenase inhibition. Clinically relevant concentrations of celecoxib can affect ionic currents and alter functioning of neurons and myocytes. In particular,...

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Detalles Bibliográficos
Autores principales: Frolov, Roman V., Ignatova, Irina I., Singh, Satpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200315/
https://www.ncbi.nlm.nih.gov/pubmed/22039467
http://dx.doi.org/10.1371/journal.pone.0026344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200315/
https://www.ncbi.nlm.nih.gov/pubmed/22039467
http://dx.doi.org/10.1371/journal.pone.0026344

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