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Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism

BACKGROUND: Celecoxib (Celebrex), a widely prescribed selective inhibitor of cyclooxygenase-2, can modulate ion channels independently of cyclooxygenase inhibition. Clinically relevant concentrations of celecoxib can affect ionic currents and alter functioning of neurons and myocytes. In particular,...

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Detalles Bibliográficos
Autores principales:	Frolov, Roman V., Ignatova, Irina I., Singh, Satpal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200315/ https://www.ncbi.nlm.nih.gov/pubmed/22039467 http://dx.doi.org/10.1371/journal.pone.0026344

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