Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase

4-Methylumbelliferone (4-MU) is described as a selective inhibitor of hyaluronan (HA) production. It is thought that 4-MU depletes UDP-glucuronic acid (UDP-GlcUA) substrate for HA synthesis and also suppresses HA-synthase expression. The possibility that 4-MU exerts at least some of its actions via...

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Detalles Bibliográficos
Autores principales: Clarkin, C.E., Allen, S., Wheeler-Jones, C.P., Bastow, E.R., Pitsillides, A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2011
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200435/
https://www.ncbi.nlm.nih.gov/pubmed/21292001
http://dx.doi.org/10.1016/j.matbio.2011.01.002

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