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9-Hy­droxy-4,8-dimethyl-12-(pyrrolidin-1-ylmeth­yl)-3,14-dioxatricyclo­[9.3.0.0(2,4)]tetra­dec-7-en-13-one

The title compound, C(19)H(29)O(4), was synthesized from 9α-hy­droxy­parthenolide (9α-hy­droxy-4,8-dimethyl-12-methylen-3,14-dioxatricyclo­[9.3.0.0(2,4)]tetra­dec-7-en-13-one), which was isolated from the chloro­form extract of the aerial parts of Anvillea radiata. The mol­ecule is built up from two...

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Detalles Bibliográficos
Autores principales: Moumou, Mohamed, Benharref, Ahmed, Avignant, Daniel, Oudahmane, Abdelghani, Akssira, Mohamed, Berraho, Moha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200593/
https://www.ncbi.nlm.nih.gov/pubmed/22065010
http://dx.doi.org/10.1107/S1600536811030467
Descripción
Sumario:The title compound, C(19)H(29)O(4), was synthesized from 9α-hy­droxy­parthenolide (9α-hy­droxy-4,8-dimethyl-12-methylen-3,14-dioxatricyclo­[9.3.0.0(2,4)]tetra­dec-7-en-13-one), which was isolated from the chloro­form extract of the aerial parts of Anvillea radiata. The mol­ecule is built up from two fused five- and ten-membered rings with the pyrrolidin-1-ylmethyl group as a substituent. The five-membered lactone ring has an envelope conformation, whereas the ten-membered and pyrrolidine rings display approximate chair–chair and twisted conformations, respectively. The dihedral angle between the ten-membered ring and the lactone ring is 18.01 (19)°. An intra­molecular O—H⋯N hydrogen bond occurs. The crystal structure is stabilized by weak inter­molecular C—H⋯O hydrogen-bonding inter­actions.