Cargando…

Tramadol hydro­chloride–benzoic acid (1/1)

In the cation of the title co-crystal salt {systematic name: [2-hydroxy-2-(3-meth­oxy­phen­yl)cyclo­hexyl­meth­yl]dimethyl­aza­nium chloride–benzoic acid (1/1)}, C(16)H(31)NO(2) (+)·Cl(−)·C(7)H(6)O(2), the N atom is protonated and the six-membered cyclo­hexane ring adopts a slightly distorted chair...

Descripción completa

Detalles Bibliográficos
Autores principales: Siddaraju, B. P., Jasinski, Jerry P., Golen, James A., Yathirajan, H. S., Raju, C. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200805/
https://www.ncbi.nlm.nih.gov/pubmed/22058967
http://dx.doi.org/10.1107/S1600536811032181
Descripción
Sumario:In the cation of the title co-crystal salt {systematic name: [2-hydroxy-2-(3-meth­oxy­phen­yl)cyclo­hexyl­meth­yl]dimethyl­aza­nium chloride–benzoic acid (1/1)}, C(16)H(31)NO(2) (+)·Cl(−)·C(7)H(6)O(2), the N atom is protonated and the six-membered cyclo­hexane ring adopts a slightly distorted chair conformation. The dihedral angle between the mean planes of the benzene rings in the cation and the benzoic acid mol­ecule is 75.5 (9)°. The crystal packing is stabilized by weak inter­molecular O—H⋯Cl, N—H⋯Cl and C—H⋯π inter­actions, forming a two-dimensional chain network along the b axis. The benzoic acid mol­ecule is not involved in the usual head-to-tail dimer bonding, but instead is linked to the ammonium cation through mutual hydrogen-bonding inter­actions with the chloride anion.