(7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane

The title compound, C(26)H(30)ClNO(4), a sinomenine derivative, has five six-membered rings, two of which are aromatic, with a dihedral angle of 34.13 (20)° between these. The N-containing ring and the fourth ring exhibit chair conformations, while the fifth ring approximates an envelope conformatio...

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Autores principales: Zheng, Xing-Liang, Jiang, Ning-Fei, Gao, Hong-Sheng, Luo, Dan, Ding, Ai-Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200812/
https://www.ncbi.nlm.nih.gov/pubmed/22059035
http://dx.doi.org/10.1107/S160053681103443X
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author Zheng, Xing-Liang
Jiang, Ning-Fei
Gao, Hong-Sheng
Luo, Dan
Ding, Ai-Shun
author_facet Zheng, Xing-Liang
Jiang, Ning-Fei
Gao, Hong-Sheng
Luo, Dan
Ding, Ai-Shun
author_sort Zheng, Xing-Liang
collection PubMed
description The title compound, C(26)H(30)ClNO(4), a sinomenine derivative, has five six-membered rings, two of which are aromatic, with a dihedral angle of 34.13 (20)° between these. The N-containing ring and the fourth ring exhibit chair conformations, while the fifth ring approximates an envelope conformation. A single inter­molecular O—H⋯N hydrogen-bonding inter­action gives a one-dimensional chain structure which extends along the a axis. The absolute configuration for the mol­ecule has been determined.
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spelling pubmed-32008122011-11-06 (7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane Zheng, Xing-Liang Jiang, Ning-Fei Gao, Hong-Sheng Luo, Dan Ding, Ai-Shun Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(26)H(30)ClNO(4), a sinomenine derivative, has five six-membered rings, two of which are aromatic, with a dihedral angle of 34.13 (20)° between these. The N-containing ring and the fourth ring exhibit chair conformations, while the fifth ring approximates an envelope conformation. A single inter­molecular O—H⋯N hydrogen-bonding inter­action gives a one-dimensional chain structure which extends along the a axis. The absolute configuration for the mol­ecule has been determined. International Union of Crystallography 2011-08-27 /pmc/articles/PMC3200812/ /pubmed/22059035 http://dx.doi.org/10.1107/S160053681103443X Text en © Zheng et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Zheng, Xing-Liang
Jiang, Ning-Fei
Gao, Hong-Sheng
Luo, Dan
Ding, Ai-Shun
(7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane
title (7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane
title_full (7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane
title_fullStr (7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane
title_full_unstemmed (7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane
title_short (7R,8S,9S,12S)-1-(4-Chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-N-methyl­morphinane
title_sort (7r,8s,9s,12s)-1-(4-chloro­benz­yloxy)-13,14-didehydro-12-hy­droxy-2,13-dimeth­oxy-n-methyl­morphinane
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200812/
https://www.ncbi.nlm.nih.gov/pubmed/22059035
http://dx.doi.org/10.1107/S160053681103443X
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