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Synthesis of enantiomerically enriched (R)-(13)C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine

The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N-naphthoyl derivatives of amino acids was used to introduce a (13)C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive alkylation of L-alanine with (13)CH(3)I. Conditi...

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Detalles Bibliográficos
Autores principales:	Fletcher, Stephen P, Solà, Jordi, Holt, Dean, Brown, Robert A, Clayden, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2011
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201042/ https://www.ncbi.nlm.nih.gov/pubmed/22043239 http://dx.doi.org/10.3762/bjoc.7.152

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