Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles

Pyrazolidinones were prepared in a two-step sequence starting from α-hydrazonocarboxylic acids. After a four-component Ugi coupling, the resulting hydrazone was engaged in a copper triggered [3 + 2] cycloaddition/aerobic oxidation cascade.

Detalles Bibliográficos
Autores principales: Santos, Aurélie Dos, El Kaim, Laurent, Grimaud, Laurence, Ronsseray, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201043/
https://www.ncbi.nlm.nih.gov/pubmed/22043240
http://dx.doi.org/10.3762/bjoc.7.153
Descripción
Sumario:Pyrazolidinones were prepared in a two-step sequence starting from α-hydrazonocarboxylic acids. After a four-component Ugi coupling, the resulting hydrazone was engaged in a copper triggered [3 + 2] cycloaddition/aerobic oxidation cascade.

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