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Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids

This paper reviews the current trends in the combined use of supported catalytic systems, either on solid supports or in liquid phases and supercritical fluids (scFs), to develop selective and enantioselective chemical transformations under continuous and semi-continuous flow conditions. The results...

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Detalles Bibliográficos
Autores principales: Burguete, M Isabel, García-Verdugo, Eduardo, Luis, Santiago V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201049/
https://www.ncbi.nlm.nih.gov/pubmed/22043246
http://dx.doi.org/10.3762/bjoc.7.159
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author Burguete, M Isabel
García-Verdugo, Eduardo
Luis, Santiago V
author_facet Burguete, M Isabel
García-Verdugo, Eduardo
Luis, Santiago V
author_sort Burguete, M Isabel
collection PubMed
description This paper reviews the current trends in the combined use of supported catalytic systems, either on solid supports or in liquid phases and supercritical fluids (scFs), to develop selective and enantioselective chemical transformations under continuous and semi-continuous flow conditions. The results presented have been selected to highlight how the combined use of those two elements can contribute to: (i) Significant improvements in productivity as a result of the enhanced diffusion of substrates and reagents through the interfaces favored by the scF phase; (ii) the long term stability of the catalytic systems, which also contributes to the improvement of the final productivity, as the use of an appropriate immobilization strategy facilitates catalyst isolation and reuse; (iii) the development of highly efficient selective or, when applicable, enantioselective chemical transformations. Although the examples reported in the literature and considered in this review are currently confined to a limited number of fields, a significant development in this area can be envisaged for the near future due to the clear advantages of these systems over the conventional ones.
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spelling pubmed-32010492011-10-31 Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids Burguete, M Isabel García-Verdugo, Eduardo Luis, Santiago V Beilstein J Org Chem Review This paper reviews the current trends in the combined use of supported catalytic systems, either on solid supports or in liquid phases and supercritical fluids (scFs), to develop selective and enantioselective chemical transformations under continuous and semi-continuous flow conditions. The results presented have been selected to highlight how the combined use of those two elements can contribute to: (i) Significant improvements in productivity as a result of the enhanced diffusion of substrates and reagents through the interfaces favored by the scF phase; (ii) the long term stability of the catalytic systems, which also contributes to the improvement of the final productivity, as the use of an appropriate immobilization strategy facilitates catalyst isolation and reuse; (iii) the development of highly efficient selective or, when applicable, enantioselective chemical transformations. Although the examples reported in the literature and considered in this review are currently confined to a limited number of fields, a significant development in this area can be envisaged for the near future due to the clear advantages of these systems over the conventional ones. Beilstein-Institut 2011-09-30 /pmc/articles/PMC3201049/ /pubmed/22043246 http://dx.doi.org/10.3762/bjoc.7.159 Text en Copyright © 2011, Burguete et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Review
Burguete, M Isabel
García-Verdugo, Eduardo
Luis, Santiago V
Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids
title Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids
title_full Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids
title_fullStr Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids
title_full_unstemmed Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids
title_short Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids
title_sort efficient and selective chemical transformations under flow conditions: the combination of supported catalysts and supercritical fluids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201049/
https://www.ncbi.nlm.nih.gov/pubmed/22043246
http://dx.doi.org/10.3762/bjoc.7.159
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