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Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters

Titanium-based Lewis acids catalyze the α-fluorination of β-ketoesters by electrophilic N–F-fluorinating reagents. Asymmetric catalysis with TADDOLato–titanium(IV) dichloride (TADDOL = α,α,α',α'-tetraaryl-(1,3-dioxolane-4,5-diyl)-dimethanol) Lewis acids produces enantiomerically enriched α...

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Detalles Bibliográficos
Autores principales:	Hintermann, Lukas, Perseghini, Mauro, Togni, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2011
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201056/ https://www.ncbi.nlm.nih.gov/pubmed/22043253 http://dx.doi.org/10.3762/bjoc.7.166

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