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XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes

Activation-induced deaminase (AID) deaminates cytosine to uracil in immunoglobulin genes. Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce single-strand breaks. The breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically t...

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Detalles Bibliográficos
Autores principales:	Saribasak, Huseyin, Maul, Robert W., Cao, Zheng, McClure, Rhonda L., Yang, William, McNeill, Daniel R., Wilson, David M., Gearhart, Patricia J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201205/ https://www.ncbi.nlm.nih.gov/pubmed/21967769 http://dx.doi.org/10.1084/jem.20111135

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