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Unraveling the basic biology and clinical significance of the chlamydial plasmid
Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding chlamydial plasmid participation in host–microbe inter...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Rockefeller University Press
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201210/ https://www.ncbi.nlm.nih.gov/pubmed/22025500 http://dx.doi.org/10.1084/jem.20112088 |
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author | Rockey, Daniel D. |
author_facet | Rockey, Daniel D. |
author_sort | Rockey, Daniel D. |
collection | PubMed |
description | Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding chlamydial plasmid participation in host–microbe interactions, disease, and immune responses. Work in mouse model systems and, very recently, in nonhuman primates demonstrates that plasmid-deficient chlamydial strains function as live attenuated vaccines against genital and ocular infections. Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections. |
format | Online Article Text |
id | pubmed-3201210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32012102012-04-24 Unraveling the basic biology and clinical significance of the chlamydial plasmid Rockey, Daniel D. J Exp Med Minireview Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding chlamydial plasmid participation in host–microbe interactions, disease, and immune responses. Work in mouse model systems and, very recently, in nonhuman primates demonstrates that plasmid-deficient chlamydial strains function as live attenuated vaccines against genital and ocular infections. Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections. The Rockefeller University Press 2011-10-24 /pmc/articles/PMC3201210/ /pubmed/22025500 http://dx.doi.org/10.1084/jem.20112088 Text en © 2011 Rockey This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Minireview Rockey, Daniel D. Unraveling the basic biology and clinical significance of the chlamydial plasmid |
title | Unraveling the basic biology and clinical significance of the chlamydial plasmid |
title_full | Unraveling the basic biology and clinical significance of the chlamydial plasmid |
title_fullStr | Unraveling the basic biology and clinical significance of the chlamydial plasmid |
title_full_unstemmed | Unraveling the basic biology and clinical significance of the chlamydial plasmid |
title_short | Unraveling the basic biology and clinical significance of the chlamydial plasmid |
title_sort | unraveling the basic biology and clinical significance of the chlamydial plasmid |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201210/ https://www.ncbi.nlm.nih.gov/pubmed/22025500 http://dx.doi.org/10.1084/jem.20112088 |
work_keys_str_mv | AT rockeydanield unravelingthebasicbiologyandclinicalsignificanceofthechlamydialplasmid |