Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma c...

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Detalles Bibliográficos
Autores principales: Liao, Hua-Xin, Chen, Xi, Munshaw, Supriya, Zhang, Ruijun, Marshall, Dawn J., Vandergrift, Nathan, Whitesides, John F., Lu, Xiaozhi, Yu, Jae-Sung, Hwang, Kwan-Ki, Gao, Feng, Markowitz, Martin, Heath, Sonya L., Bar, Katharine J., Goepfert, Paul A., Montefiori, David C., Shaw, George C., Alam, S. Munir, Margolis, David M., Denny, Thomas N., Boyd, Scott D., Marshal, Eleanor, Egholm, Michael, Simen, Birgitte B., Hanczaruk, Bozena, Fire, Andrew Z., Voss, Gerald, Kelsoe, Garnett, Tomaras, Georgia D., Moody, M. Anthony, Kepler, Thomas B., Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201211/
https://www.ncbi.nlm.nih.gov/pubmed/21987658
http://dx.doi.org/10.1084/jem.20110363

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