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rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one
The chiral title compound, C(21)H(20)N(4)O(2), crystallizes as a racemic mixture. In the crystal, molecules form centrosymmetric π-overlapping dimers [interplanar distance = 3.338 (6) Å], which are further connected along the a axis forming centrosymmetric dimers via O—H⋯N hydrogen bonds. C—H⋯O in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201358/ https://www.ncbi.nlm.nih.gov/pubmed/22065467 http://dx.doi.org/10.1107/S1600536811037408 |
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author | Rodstein, Matthew E. Steffen, Paul D. Krivogorsky, Bogdana Grundt, Peter |
author_facet | Rodstein, Matthew E. Steffen, Paul D. Krivogorsky, Bogdana Grundt, Peter |
author_sort | Rodstein, Matthew E. |
collection | PubMed |
description | The chiral title compound, C(21)H(20)N(4)O(2), crystallizes as a racemic mixture. In the crystal, molecules form centrosymmetric π-overlapping dimers [interplanar distance = 3.338 (6) Å], which are further connected along the a axis forming centrosymmetric dimers via O—H⋯N hydrogen bonds. C—H⋯O interactions are also observed. The indolo[2,1-b]quinazoline group is somewhat bent, with a small dihedral angle of 6.3 (4)° between the plane of the quinazoline system and the plane of the benzene ring of the indole moiety. The C=N—N=C atoms of the azine group is oriented almost perpendicular [84.1 (2)°] to the mean plane of the quinazoline system. |
format | Online Article Text |
id | pubmed-3201358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32013582011-11-06 rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one Rodstein, Matthew E. Steffen, Paul D. Krivogorsky, Bogdana Grundt, Peter Acta Crystallogr Sect E Struct Rep Online Organic Papers The chiral title compound, C(21)H(20)N(4)O(2), crystallizes as a racemic mixture. In the crystal, molecules form centrosymmetric π-overlapping dimers [interplanar distance = 3.338 (6) Å], which are further connected along the a axis forming centrosymmetric dimers via O—H⋯N hydrogen bonds. C—H⋯O interactions are also observed. The indolo[2,1-b]quinazoline group is somewhat bent, with a small dihedral angle of 6.3 (4)° between the plane of the quinazoline system and the plane of the benzene ring of the indole moiety. The C=N—N=C atoms of the azine group is oriented almost perpendicular [84.1 (2)°] to the mean plane of the quinazoline system. International Union of Crystallography 2011-09-30 /pmc/articles/PMC3201358/ /pubmed/22065467 http://dx.doi.org/10.1107/S1600536811037408 Text en © Rodstein et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Rodstein, Matthew E. Steffen, Paul D. Krivogorsky, Bogdana Grundt, Peter rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one |
title |
rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one |
title_full |
rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one |
title_fullStr |
rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one |
title_full_unstemmed |
rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one |
title_short |
rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one |
title_sort | rac-(6s)-6-hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6h)-one |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201358/ https://www.ncbi.nlm.nih.gov/pubmed/22065467 http://dx.doi.org/10.1107/S1600536811037408 |
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