(4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline

The title compound, C(21)H(18)ClN, was synthesized by an enanti­oselective Brønsted acid-catalysed transfer hydrogenation reaction. The six-membered heterocycle adopts a half-chair conformation. It has the biphenyl residue in an axial position. The two rings of the biphenyl residue are almost coplan...

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Detalles Bibliográficos
Autores principales: Theissmann, Thomas, Bolte, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201410/
https://www.ncbi.nlm.nih.gov/pubmed/22064825
http://dx.doi.org/10.1107/S160053681103830X
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author Theissmann, Thomas
Bolte, Michael
author_facet Theissmann, Thomas
Bolte, Michael
author_sort Theissmann, Thomas
collection PubMed
description The title compound, C(21)H(18)ClN, was synthesized by an enanti­oselective Brønsted acid-catalysed transfer hydrogenation reaction. The six-membered heterocycle adopts a half-chair conformation. It has the biphenyl residue in an axial position. The two rings of the biphenyl residue are almost coplanar [dihedral angle = 2.65 (9)°]. The crystal packing is stabilized by N—H⋯Cl hydrogen bonds, which connect the mol­ecules into chains running along the a axis.
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spelling pubmed-32014102011-11-06 (4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline Theissmann, Thomas Bolte, Michael Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(21)H(18)ClN, was synthesized by an enanti­oselective Brønsted acid-catalysed transfer hydrogenation reaction. The six-membered heterocycle adopts a half-chair conformation. It has the biphenyl residue in an axial position. The two rings of the biphenyl residue are almost coplanar [dihedral angle = 2.65 (9)°]. The crystal packing is stabilized by N—H⋯Cl hydrogen bonds, which connect the mol­ecules into chains running along the a axis. International Union of Crystallography 2011-09-30 /pmc/articles/PMC3201410/ /pubmed/22064825 http://dx.doi.org/10.1107/S160053681103830X Text en © Theissmann and Bolte 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Theissmann, Thomas
Bolte, Michael
(4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline
title (4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline
title_full (4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline
title_fullStr (4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline
title_full_unstemmed (4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline
title_short (4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline
title_sort (4r)-4-(biphenyl-4-yl)-7-chloro-1,2,3,4-tetra­hydro­quinoline
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201410/
https://www.ncbi.nlm.nih.gov/pubmed/22064825
http://dx.doi.org/10.1107/S160053681103830X
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AT boltemichael 4r4biphenyl4yl7chloro1234tetrahydroquinoline

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