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Bupropion hydro­bromide propanol hemisolvate

The title compound {systematic name: N-[1-(3-chloro­phen­yl)-1-oxopropan-2-yl]-tert-butanaminium bromide propanol hemisolvate}, C(13)H(19)ClNO(+)·Br(−)·0.5C(3)H(8)O, crystallizes with two independent bupropion hydro­bromide ion pairs and a solvent 1-propanol mol­ecule in the asymmetric unit. In both...

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Detalles Bibliográficos
Autores principales: Liu, Min, Hu, Xiu-Rong, Gu, Jian-Ming, Tang, Gu-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201450/
https://www.ncbi.nlm.nih.gov/pubmed/22064727
http://dx.doi.org/10.1107/S1600536811037093
Descripción
Sumario:The title compound {systematic name: N-[1-(3-chloro­phen­yl)-1-oxopropan-2-yl]-tert-butanaminium bromide propanol hemisolvate}, C(13)H(19)ClNO(+)·Br(−)·0.5C(3)H(8)O, crystallizes with two independent bupropion hydro­bromide ion pairs and a solvent 1-propanol mol­ecule in the asymmetric unit. In both mol­ecules, the expected proton transfer from HBr to the amino group of the bupropion mol­ecule is observed, and intra- and inter­molecular N—H⋯Br hydrogen-bond inter­actions are formed. These inter­actions link the mol­ecules into hydrogen-bond dimers. The side chains of the two cations have slightly different orientations. The 1-propanol solvent mol­ecule is linked to a bromide ion by an O—H⋯Br hydrogen bond.