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Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure

Pregnane X receptor (PXR), acting as a xenobiotic-activated transcription factor, regulates the hepatic metabolism of therapeutics as well as endobiotics such as steroid hormones. Given our finding that PXR activation by rifampicin (RIF) represses the estrogen sulfotransferase (SULT1E1) gene in huma...

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Detalles Bibliográficos
Autores principales:	Kodama, Susumu, Hosseinpour, Fardin, Goldstein, Joyce A., Negishi, Masahiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201858/ https://www.ncbi.nlm.nih.gov/pubmed/21764778 http://dx.doi.org/10.1093/nar/gkr458

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