Cargando…

Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation

RNA structure plays a fundamental role in internal initiation of translation. Picornavirus internal ribosome entry site (IRES) are long, efficient cis-acting elements that recruit the ribosome to internal mRNA sites. However, little is known about long-range constraints determining the IRES RNA stru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández, Noemí, Fernandez-Miragall, Olga, Ramajo, Jorge, García-Sacristán, Ana, Bellora, Nicolás, Eyras, Eduardo, Briones, Carlos, Martínez-Salas, Encarnación
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201876/ https://www.ncbi.nlm.nih.gov/pubmed/21742761 http://dx.doi.org/10.1093/nar/gkr560

Ejemplares similares

Gemin5 promotes IRES interaction and translation control through its C-terminal region
por: Piñeiro, David, et al.
Publicado: (2013)

Designing synthetic RNAs to determine the relevance of structural motifs in picornavirus IRES elements
por: Fernandez-Chamorro, Javier, et al.
Publicado: (2016)

Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine
por: Yang, Lin, et al.
Publicado: (2010)

HCV IRES interacts with the 18S rRNA to activate the 40S ribosome for subsequent steps of translation initiation
por: Malygin, Alexey A., et al.
Publicado: (2013)

Translational control of the interferon regulatory factor 2 mRNA by IRES element
por: Dhar, Debojyoti, et al.
Publicado: (2007)

Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation
por: Barrera, Aldo, et al.
Publicado: (2020)

Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation
por: Andreev, Dmitri E., et al.
Publicado: (2012)

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation
por: Sun, Chaomin, et al.
Publicado: (2013)

Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus
por: Asnani, Mukta, et al.
Publicado: (2016)

LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex
por: Angulo, Jenniffer, et al.
Publicado: (2016)

Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1
por: Park, Sung Mi, et al.
Publicado: (2011)

The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation
por: Francisco-Velilla, Rosario, et al.
Publicado: (2018)

Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES–driven RNA localization
por: Fernandez-Chamorro, Javier, et al.
Publicado: (2019)

RNAiFold2T: Constraint Programming design of thermo-IRES switches
por: Garcia-Martin, Juan Antonio, et al.
Publicado: (2016)

Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation
por: Lozano, Gloria, et al.
Publicado: (2015)

A novel role for Gemin5 in mRNA translation
por: Pacheco, Almudena, et al.
Publicado: (2009)

Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions
por: Khan, Mateen A., et al.
Publicado: (2014)

The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators
por: Llorian, Miriam, et al.
Publicado: (2016)

Identification of a consensus element recognized and cleaved by IRE1α
por: Oikawa, Daisuke, et al.
Publicado: (2010)

Structure of the PCBP2/stem–loop IV complex underlying translation initiation mediated by the poliovirus type I IRES
por: Beckham, Simone A, et al.
Publicado: (2020)

Attachment of ribosomal complexes and retrograde scanning during initiation on the Halastavi árva virus IRES
por: Abaeva, Irina S., et al.
Publicado: (2016)

End-to-end crosstalk within the hepatitis C virus genome mediates the conformational switch of the 3′X-tail region
por: Romero-López, Cristina, et al.
Publicado: (2014)

The folding of the hepatitis C virus internal ribosome entry site depends on the 3′-end of the viral genome
por: Romero-López, Cristina, et al.
Publicado: (2012)

Functional and Structural Analysis of Maize Hsp101 IRES
por: Jiménez-González, Augusto Samuel, et al.
Publicado: (2014)

Magnesium‐dependent folding of a picornavirus IRES element modulates RNA conformation and eIF4G interaction
por: Lozano, Gloria, et al.
Publicado: (2014)

The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation
por: Ramos, Hade, et al.
Publicado: (2021)

In-cell SHAPE uncovers dynamic interactions between the untranslated regions of the foot-and-mouth disease virus RNA
por: Diaz-Toledano, Rosa, et al.
Publicado: (2017)

Cell type specificity and structural determinants of IRES activity from the 5′ leaders of different HIV-1 transcripts
por: Plank, Terra-Dawn M., et al.
Publicado: (2013)

The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation
por: Francisco-Velilla, Rosario, et al.
Publicado: (2016)

A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells
por: Weng, Kuo-Feng, et al.
Publicado: (2014)

A new type of IRES within gag coding region recruits three initiation complexes on HIV-2 genomic RNA
por: Weill, Laure, et al.
Publicado: (2010)

PCBP2 enables the cadicivirus IRES to exploit the function of a conserved GRNA tetraloop to enhance ribosomal initiation complex formation
por: Asnani, Mukta, et al.
Publicado: (2016)

Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression
por: Shen, Manli, et al.
Publicado: (2011)

The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function
por: Bhat, Prasanna, et al.
Publicado: (2015)

A magnesium-induced RNA conformational switch at the internal ribosome entry site of hepatitis C virus genome visualized by atomic force microscopy
por: García-Sacristán, Ana, et al.
Publicado: (2015)

Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors
por: Vallejos, Maricarmen, et al.
Publicado: (2011)

A Combined ELONA-(RT)qPCR Approach for Characterizing DNA and RNA Aptamers Selected against PCBP-2
por: Moreno, Miguel, et al.
Publicado: (2019)

Horizontal gene transfer as a mechanism for the promiscuous acquisition of distinct classes of IRES by avian caliciviruses
por: Arhab, Yani, et al.
Publicado: (2021)

Insights into Structural and Mechanistic Features of Viral IRES Elements
por: Martinez-Salas, Encarnacion, et al.
Publicado: (2018)

Comparison of mRNA features affecting translation initiation and reinitiation
por: Osterman, Ilya A., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_j7ve7v6lihuu228ah0pfetaha8