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Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens
BACKGROUND: Boswellic acids mixture of triterpenic acids obtained from the oleo gum resin of Boswellia serrata and known for its effectiveness in the treatment of chronic inflammatory disease including peritumor edema. Boswellic acids have been extensively studied for a number of activities includin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201914/ https://www.ncbi.nlm.nih.gov/pubmed/21992439 http://dx.doi.org/10.1186/1756-0500-4-406 |
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author | Raja, Alsaba F Ali, Furqan Khan, Inshad A Shawl, Abdul S Arora, Daljit S |
author_facet | Raja, Alsaba F Ali, Furqan Khan, Inshad A Shawl, Abdul S Arora, Daljit S |
author_sort | Raja, Alsaba F |
collection | PubMed |
description | BACKGROUND: Boswellic acids mixture of triterpenic acids obtained from the oleo gum resin of Boswellia serrata and known for its effectiveness in the treatment of chronic inflammatory disease including peritumor edema. Boswellic acids have been extensively studied for a number of activities including anti inflammatory, antitumor, immunomodulatory, and inflammatory bowel diseases. The present study describes the antimicrobial activities of boswellic acid molecules against oral cavity pathogens. Acetyl-11-keto-β-boswellic acid (AKBA), which exhibited the most potent antibacterial activity, was further evaluated in time kill studies, mutation prevention frequency, postantibiotic effect (PAE) and biofilm susceptibility assay against oral cavity pathogens. FINDINGS: AKBA exhibited an inhibitory effect on all the oral cavity pathogens tested (MIC of 2-4 μg/ml). It exhibited concentration dependent killing of Streptococcus mutans ATCC 25175 up to 8 × MIC and also prevented the emergence of mutants of S.mutans ATCC 25175 at 8× MIC. AKBA demonstrated postantibiotic effect (PAE) of 5.7 ± 0.1 h at 2 × MIC. Furthermore, AKBA inhibited the formation of biofilms generated by S.mutans and Actinomyces viscosus and also reduced the preformed biofilms by these bacteria. CONCLUSIONS: AKBA can be useful compound for the development of antibacterial agent against oral pathogens and it has great potential for use in mouthwash for preventing and treating oral infections. |
format | Online Article Text |
id | pubmed-3201914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32019142011-10-26 Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens Raja, Alsaba F Ali, Furqan Khan, Inshad A Shawl, Abdul S Arora, Daljit S BMC Res Notes Short Report BACKGROUND: Boswellic acids mixture of triterpenic acids obtained from the oleo gum resin of Boswellia serrata and known for its effectiveness in the treatment of chronic inflammatory disease including peritumor edema. Boswellic acids have been extensively studied for a number of activities including anti inflammatory, antitumor, immunomodulatory, and inflammatory bowel diseases. The present study describes the antimicrobial activities of boswellic acid molecules against oral cavity pathogens. Acetyl-11-keto-β-boswellic acid (AKBA), which exhibited the most potent antibacterial activity, was further evaluated in time kill studies, mutation prevention frequency, postantibiotic effect (PAE) and biofilm susceptibility assay against oral cavity pathogens. FINDINGS: AKBA exhibited an inhibitory effect on all the oral cavity pathogens tested (MIC of 2-4 μg/ml). It exhibited concentration dependent killing of Streptococcus mutans ATCC 25175 up to 8 × MIC and also prevented the emergence of mutants of S.mutans ATCC 25175 at 8× MIC. AKBA demonstrated postantibiotic effect (PAE) of 5.7 ± 0.1 h at 2 × MIC. Furthermore, AKBA inhibited the formation of biofilms generated by S.mutans and Actinomyces viscosus and also reduced the preformed biofilms by these bacteria. CONCLUSIONS: AKBA can be useful compound for the development of antibacterial agent against oral pathogens and it has great potential for use in mouthwash for preventing and treating oral infections. BioMed Central 2011-10-13 /pmc/articles/PMC3201914/ /pubmed/21992439 http://dx.doi.org/10.1186/1756-0500-4-406 Text en Copyright ©2011 Raja et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Raja, Alsaba F Ali, Furqan Khan, Inshad A Shawl, Abdul S Arora, Daljit S Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens |
title | Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens |
title_full | Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens |
title_fullStr | Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens |
title_full_unstemmed | Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens |
title_short | Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens |
title_sort | acetyl-11-keto-β-boswellic acid (akba); targeting oral cavity pathogens |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201914/ https://www.ncbi.nlm.nih.gov/pubmed/21992439 http://dx.doi.org/10.1186/1756-0500-4-406 |
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