Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection

Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the ant...

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Detalles Bibliográficos
Autores principales: Huth, M. E., Ricci, A. J., Cheng, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202092/
https://www.ncbi.nlm.nih.gov/pubmed/22121370
http://dx.doi.org/10.1155/2011/937861
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author Huth, M. E.
Ricci, A. J.
Cheng, A. G.
author_facet Huth, M. E.
Ricci, A. J.
Cheng, A. G.
author_sort Huth, M. E.
collection PubMed
description Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. These mechanisms are reviewed in regard to established and potential future targets of hair cell protection.
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spelling pubmed-32020922011-11-25 Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection Huth, M. E. Ricci, A. J. Cheng, A. G. Int J Otolaryngol Review Article Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. These mechanisms are reviewed in regard to established and potential future targets of hair cell protection. Hindawi Publishing Corporation 2011 2011-10-25 /pmc/articles/PMC3202092/ /pubmed/22121370 http://dx.doi.org/10.1155/2011/937861 Text en Copyright © 2011 M. E. Huth et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Huth, M. E.
Ricci, A. J.
Cheng, A. G.
Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
title Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
title_full Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
title_fullStr Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
title_full_unstemmed Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
title_short Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
title_sort mechanisms of aminoglycoside ototoxicity and targets of hair cell protection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202092/
https://www.ncbi.nlm.nih.gov/pubmed/22121370
http://dx.doi.org/10.1155/2011/937861
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