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Splicing Programs and Cancer
Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level. G...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202119/ https://www.ncbi.nlm.nih.gov/pubmed/22132318 http://dx.doi.org/10.1155/2012/269570 |
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author | Germann, Sophie Gratadou, Lise Dutertre, Martin Auboeuf, Didier |
author_facet | Germann, Sophie Gratadou, Lise Dutertre, Martin Auboeuf, Didier |
author_sort | Germann, Sophie |
collection | PubMed |
description | Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level. Genome-wide analyses of alternative splicing indicate that splicing alterations can affect the products of gene networks involved in key cellular programs. In addition, many splicing variants identified as being misregulated in cancer are expressed in normal tissues. These observations suggest that splicing programs contribute to specific cellular programs that are altered during cancer initiation and progression. Supporting this model, recent studies have identified splicing factors controlling cancer-associated splicing programs. The characterization of splicing programs and their regulation by splicing factors will allow a better understanding of the genetic mechanisms involved in cancer initiation and progression and the development of new therapeutic targets. |
format | Online Article Text |
id | pubmed-3202119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32021192011-11-30 Splicing Programs and Cancer Germann, Sophie Gratadou, Lise Dutertre, Martin Auboeuf, Didier J Nucleic Acids Review Article Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level. Genome-wide analyses of alternative splicing indicate that splicing alterations can affect the products of gene networks involved in key cellular programs. In addition, many splicing variants identified as being misregulated in cancer are expressed in normal tissues. These observations suggest that splicing programs contribute to specific cellular programs that are altered during cancer initiation and progression. Supporting this model, recent studies have identified splicing factors controlling cancer-associated splicing programs. The characterization of splicing programs and their regulation by splicing factors will allow a better understanding of the genetic mechanisms involved in cancer initiation and progression and the development of new therapeutic targets. Hindawi Publishing Corporation 2012 2011-10-24 /pmc/articles/PMC3202119/ /pubmed/22132318 http://dx.doi.org/10.1155/2012/269570 Text en Copyright © 2012 Sophie Germann et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Germann, Sophie Gratadou, Lise Dutertre, Martin Auboeuf, Didier Splicing Programs and Cancer |
title | Splicing Programs and Cancer |
title_full | Splicing Programs and Cancer |
title_fullStr | Splicing Programs and Cancer |
title_full_unstemmed | Splicing Programs and Cancer |
title_short | Splicing Programs and Cancer |
title_sort | splicing programs and cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202119/ https://www.ncbi.nlm.nih.gov/pubmed/22132318 http://dx.doi.org/10.1155/2012/269570 |
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