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Improving Islet Engraftment by Gene Therapy
Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon is...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202131/ https://www.ncbi.nlm.nih.gov/pubmed/22132301 http://dx.doi.org/10.1155/2011/594851 |
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author | Wang, Xiaojie Meloche, Mark Verchere, C. Bruce Ou, Dawei Mui, Alice Warnock, Garth L. |
author_facet | Wang, Xiaojie Meloche, Mark Verchere, C. Bruce Ou, Dawei Mui, Alice Warnock, Garth L. |
author_sort | Wang, Xiaojie |
collection | PubMed |
description | Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon islet infusion, hypoxia induced by the low oxygenated milieu, and poor-revascularization-mediated lack of nutrients, and impaired hormone modulation in the local transplanted site. Strategies using genetic modification methods through overexpression or silencing of those proteins involved in promoting new formation of blood vessels or inhibition of apoptosis may overcome these hurdles and improve islet engraftment outcomes. |
format | Online Article Text |
id | pubmed-3202131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32021312011-11-30 Improving Islet Engraftment by Gene Therapy Wang, Xiaojie Meloche, Mark Verchere, C. Bruce Ou, Dawei Mui, Alice Warnock, Garth L. J Transplant Review Article Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon islet infusion, hypoxia induced by the low oxygenated milieu, and poor-revascularization-mediated lack of nutrients, and impaired hormone modulation in the local transplanted site. Strategies using genetic modification methods through overexpression or silencing of those proteins involved in promoting new formation of blood vessels or inhibition of apoptosis may overcome these hurdles and improve islet engraftment outcomes. Hindawi Publishing Corporation 2011 2011-10-24 /pmc/articles/PMC3202131/ /pubmed/22132301 http://dx.doi.org/10.1155/2011/594851 Text en Copyright © 2011 Xiaojie Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Xiaojie Meloche, Mark Verchere, C. Bruce Ou, Dawei Mui, Alice Warnock, Garth L. Improving Islet Engraftment by Gene Therapy |
title | Improving Islet Engraftment by Gene Therapy |
title_full | Improving Islet Engraftment by Gene Therapy |
title_fullStr | Improving Islet Engraftment by Gene Therapy |
title_full_unstemmed | Improving Islet Engraftment by Gene Therapy |
title_short | Improving Islet Engraftment by Gene Therapy |
title_sort | improving islet engraftment by gene therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202131/ https://www.ncbi.nlm.nih.gov/pubmed/22132301 http://dx.doi.org/10.1155/2011/594851 |
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