Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.

1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselecti...

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Detalles Bibliográficos
Autores principales: Marunaka, Y, Niisato, N, Ito, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202177/
https://www.ncbi.nlm.nih.gov/pubmed/10981510
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author Marunaka, Y
Niisato, N
Ito, Y
author_facet Marunaka, Y
Niisato, N
Ito, Y
author_sort Marunaka, Y
collection PubMed
description 1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) channel by elongating the open time of the channel. 3) cAMP signals were converted to a protein tyrosine kinase (PTK)-mediated signal. 4) The PTK-mediated signal was involved in the cAMP-stimulated Na+ transport in rat FDLE cells.
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spelling pubmed-32021772011-10-27 Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase. Marunaka, Y Niisato, N Ito, Y J Korean Med Sci Research Article 1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) channel by elongating the open time of the channel. 3) cAMP signals were converted to a protein tyrosine kinase (PTK)-mediated signal. 4) The PTK-mediated signal was involved in the cAMP-stimulated Na+ transport in rat FDLE cells. Korean Academy of Medical Sciences 2000-08 /pmc/articles/PMC3202177/ /pubmed/10981510 Text en
spellingShingle Research Article
Marunaka, Y
Niisato, N
Ito, Y
Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.
title Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.
title_full Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.
title_fullStr Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.
title_full_unstemmed Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.
title_short Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.
title_sort beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202177/
https://www.ncbi.nlm.nih.gov/pubmed/10981510
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AT niisaton betaagonistregulationofsodiumtransportinfetallungepitheliumrolesofcellvolumecytosolicchlorideandproteintyrosinekinase
AT itoy betaagonistregulationofsodiumtransportinfetallungepitheliumrolesofcellvolumecytosolicchlorideandproteintyrosinekinase

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